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This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.
This study tests relationships among neural and behavioral valuation mechanisms, and how these mechanisms change (or not) over time, with task instructions, and following cognitive behavior therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cognitive behavioral therapy | Active Comparator | cognitive behavioral therapy for depression, anxiety, and/or anhedonia |
|
| Valuation with instruction | Active Comparator | repeat laboratory sessions of a reward/loss learning computer game with specific instructions |
|
| Valuation without instruction | Active Comparator | repeat laboratory sessions of a reward/loss learning computer game without specific instructions |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cognitive behavioral therapy | Behavioral | cognitive behavioral therapy |
| |
| Measure | Description | Time Frame |
|---|---|---|
| change in proportion correct on the 'N-arm bandit learning task' | change in proportion correct on 'N-arm bandit reinforcement learning task' from study entrance to study exit | study entrance to study exit, an average of 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| change in depression symptoms (Beck Depression Inventory) | change in depression symptoms from study entrance to study exit | study entrance to exit, an average of 12 weeks |
| change in anxiety symptoms (anxiety subscale; Mood and Anxiety Symptom Questionnaire) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fralin Biomedical Research Institute at Virginia Tech Carilion | Recruiting | Roanoke | Virginia | 24014 | United States |
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| ID | Term |
|---|---|
| D003863 | Depression |
| D001008 | Anxiety Disorders |
| D059445 | Anhedonia |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D001523 | Mental Disorders |
| D019954 | Neurobehavioral Manifestations |
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| ID | Term |
|---|---|
| D015928 | Cognitive Behavioral Therapy |
| D004522 | Educational Status |
| ID | Term |
|---|---|
| D001521 | Behavior Therapy |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
| D012959 | Socioeconomic Factors |
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| valuation with instruction |
| Behavioral |
repeat laboratory sessions of computerized learning game |
|
| valuation without instruction | Behavioral | repeat laboratory sessions of computerized learning game |
|
change in anxiety symptoms from study entrance to study exit |
| study entrance to exit, an average of 12 weeks |
| change in anhedonia symptoms (anhedonia subscale; Mood and Anxiety Symptom Questionnaire) | change in anhedonia symptoms from study entrance to study exit | study entrance to exit, an average of 12 weeks |
| D009461 |
| Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011154 | Population Characteristics |