Skeletal Muscle and Adipose Tissue Responses After Acute Exercise: Comparing Effects of Three Different Intensities

Skeletal Muscle and Adipose Tissue Responses After Acute Exercise: Comparing Effects of Three Different Intensities

The study will assess the exercise-induced changes in chromatin accessibility and gene expression in a cell type-specific manner in skeletal muscle from healthy adults in response to exercise at three different intensities - 1) low-intensity continuous exercise, 2) moderate-intensity continuous exercise, and 3) high-intensity interval exercise.

Inclusion Criteria:

• Age:18-40
• Body Mass Index: 20-30 kg/m2
• Must engage in regularly planned aerobic-type exercise at moderate-vigorous intensity, 3 times per week for at least 30-60 minutes/session
• Women must have regularly occurring menses and must be premenopausal
• Subject willingness to opt-in for the Michigan Genomics Initiative (MGI) Repository

Exclusion Criteria:

• Evidence/history of cardiovascular or metabolic disease.
• Taking anti-coagulate medications or medications known to affect metabolism or inflammation
• Weight instability ≥ ±3kg in the last 6 months
• Tobacco or e-cigarette users
• Women must not be pregnant or actively lactating