Genetic Research of Monogenic Obesity in a Pediatric Cohort With Severe and Early Onset Obesity

Genetic Research of Monogenic Obesity in a Pediatric Cohort With Severe and Early Onset Obesity

Obesity is a frequent disease mainly caused by environmental/polygenic factors and more rarely caused by the alteration of a single gene ("monogenic obesity"). The diagnosis of these rare forms can lead to personalized management (new treatments, prognosis, adapted hygienic and dietary rules) and family screening. The use of a panel covering the known causes of monogenic obesity on a pediatric cohort of severe and early obesity will allow to evaluate the relevance of these analyses to adapt the management of this type of patients.

Inclusion Criteria:

• Recruitment age: 2-17 years
• Body mass index, greater than the International Obesity Task Force (IOTF) 30 curve before the age of 5
• Care at the specialized pediatric obesity center (CSO) of the Bordeaux University Hospital
• Informed consent signed

Exclusion Criteria:

• no informed consent