Creation of a Probabilistic Atlas of Normal Cerebral Uptake of 18F-FDG in PET/MRI.

Creation of a Probabilistic Atlas of Normal Cerebral Uptake of 18F-FDG in PET/MRI.

With 18F-FDG PET, we have few atlases of normality allowing the realization of objective quantitative analyses. An atlas of normality is a probabilistic atlas of normal FDG uptake from a representative set of brain PET images of healthy subjects. This type of atlas is essential for intra- and inter-individual comparisons.

Accurate quantitative analysis of brain 18F-FDG PET images acquired on a hybrid PET system has been shown to require an institutional normal database for statistical analyzes (Akdemir et al., JNM 2017 and Della Rosa et al Neuroinformatics, 2014).

This is a prospective, monocentric, non-randomized study, with no direct individual benefit since it involved healthy volunteers.

Inclusion Criteria:

• Male or female aged 20 to 50
• Absence of any history or cardiovascular, neurological or psychiatric deficit
• Signed the informed consent

Exclusion Criteria:

• Contraindication to the realization of an MRI or PET and to the injection of 18F-FDG
• People using a pacemaker or insulin pump
• People wearing a metal prosthesis or an intracerebral clip
• People with intraocular metal splinters
• People with a pathology considered incompatible for the production of the atlas according to the investigator
• Pregnant women and breastfeeding women
• Subject in period of exclusion.