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Recent evidence suggests that curcumin supplementation may reduce muscle inflammation, oxidative markers, and muscle damage. The most favourable dosage to elicit these ergogenic effects are yet to be established; both 750mg & 1500mg has been shown to be effective. Curcumin supplementation has been ingested in numerous different ways however, no previous research to date has used curcumin in a hydrolysed (drinkable) format. The aim of this study is to investigate whether hydrolysed curcumin can reduce indices of muscle damage and improve recovery, whilst also examining a potential dose-response effect.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Curcumin Single | Experimental | The Single dose group will consume 1 placebo sachet and one curcumin sachet per day. Curcumin supplementation will be from YourZooki, the supplement in question is commercially offered to the public in a tangerine flavour. The sachets will be in 750mg hydrolysed format. The placebo is a sachet containing the same ingredients mentioned above minus the curcumin. The sachets will be in 750mg hydrolysed format. Supplementation will be administered and commence 48-hours prior to the first testing day and will be consumed twice a day (8am & 8pm). |
|
| Curcumin Double | Experimental | The double dose group will consume two sachets per day of curcumin. Curcumin supplementation will be from YourZooki, the supplement in question is commercially offered to the public in a tangerine flavour. The sachets will be in 750mg hydrolysed format. Supplementation will be administered and commence 48-hours prior to the first testing day and will be consumed twice a day (8am & 8pm). |
|
| Placebo | No Intervention | Placebo sachets containing the same ingredients mentioned above minus the curcumin. The sachets will be in 750mg hydrolysed format. Participants will consume two sachets per day. Supplementation will be administered and commence 48-hours prior to the first testing day and will be consumed twice a day (8am & 8pm). |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Curcumin | Dietary Supplement | Curcumin Supplementation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood markers | Blood samples will be taken for analysis of markers of IL-6, IL-1β, TNF-α, IL-1, IL-4, IL-10 and CK will be taken | Baseline |
| Blood markers | Blood samples will be taken for analysis of markers of IL-6, IL-1β, TNF-α, IL-1, IL-4, IL-10 and CK will be taken | immediately post muscle damage intervention |
| Blood markers | Blood samples will be taken for analysis of markers of IL-6, IL-1β, TNF-α, IL-1, IL-4, IL-10 and CK will be taken | 24 hours post |
| Blood markers | Blood samples will be taken for analysis of markers of IL-6, IL-1β, TNF-α, IL-1, IL-4, IL-10 and CK will be taken | 48 hours post |
| Blood markers | Blood samples will be taken for analysis of markers of IL-6, IL-1β, TNF-α, IL-1, IL-4, IL-10 and CK will be taken | 72 hours post |
| Ford and Fort | Capillary sample Ford and Fort tests | Baseline |
| Ford and Fort | Capillary sample Ford and Fort tests | Immediately post muscle damage intervention |
| Ford and Fort | Capillary sample Ford and Fort tests |
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Inclusion Criteria:
Inclusion criteria are as follows:
Exclusion Criteria:
Exclusion criteria include:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Luke Hughes, PhD | Contact | +447920004214 | luke4.hughes@northumbria.ac.uk | |
| Ian Grant, MSc | Contact | 020 8240 4000 | ian.grant@stmarys.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Luke Hughes, PhD | Northumbria University | Principal Investigator |
| Jess Hill, PhD | St. Mary's University, Twickenham | Principal Investigator |
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| ID | Term |
|---|---|
| D003474 | Curcumin |
| ID | Term |
|---|---|
| D036381 | Diarylheptanoids |
| D006536 | Heptanes |
| D000473 | Alkanes |
| D006839 | Hydrocarbons, Acyclic |
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| 24 hours post |
| Ford and Fort | Capillary sample Ford and Fort tests | 48 hours post |
| Ford and Fort | Capillary sample Ford and Fort tests | 72 hours post |
| Soreness | Perceived muscle soreness scale - Visual analouge scale | Baseline |
| Soreness | Perceived muscle soreness scale - Visual analouge scale | Immediately post muscle damage intervention |
| Soreness | Perceived muscle soreness scale - Visual analouge scale | 24 hours post |
| Soreness | Perceived muscle soreness scale - Visual analouge scale | 48 hours post |
| Soreness | Perceived muscle soreness scale - Visual analouge scale | 72 hours post |
| Soreness | BORG CR-10 scale | Baseline |
| Soreness | BORG CR-10 scale | Immediately post muscle damage intervention |
| Soreness | BORG CR-10 scale | 24 hours post |
| Soreness | BORG CR-10 scale | 48 hours post |
| Soreness | BORG CR-10 scale | 72 hours post |
| Soreness | Pressure pain threshold | Baseline |
| Soreness | Pressure pain threshold | Immediately post muscle damage intervention |
| Soreness | Pressure pain threshold | 24 hours post |
| Soreness | Pressure pain threshold | 48 hours post |
| Soreness | Pressure pain threshold | 72 hours post |
| Muscle Structure | Muscle swelling - thigh girth + Ultrasound measurement | Baseline |
| Muscle Structure | Muscle swelling - thigh girth + Ultrasound measurement | Immediately post muscle damage intervention |
| Muscle Structure | Muscle swelling - thigh girth + Ultrasound measurement | 24 hours post |
| Muscle Structure | Muscle swelling - thigh girth + Ultrasound measurement | 48 hours post |
| Muscle Structure | Muscle swelling - thigh girth + Ultrasound measurement | 72 hours post |
| Muscle Function | maximal strength | Baseline |
| Muscle Function | maximal strength | Immediately post muscle damage intervention |
| Muscle Function | maximal strength | 24 hours post |
| Muscle Function | maximal strength | 48 hours post |
| Muscle Function | maximal strength | 72 hours post |
| Muscle Function | Muscular endurance | Baseline |
| Muscle Function | Muscular endurance | Immediately post muscle damage intervention |
| Muscle Function | Muscular endurance | 24 hours post |
| Muscle Function | Muscular endurance | 48 hours post |
| Muscle Function | Muscular endurance | 72 hours post |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |