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| Name | Class |
|---|---|
| Atlantia Food Clinical Trials | INDUSTRY |
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The objective of the study is to test the capacity of a five-day supplementation of Turmipure Gold® to improve exercise-induced muscle pain and function recovery in moderately active adults after exercise-induced muscle damage
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Randomized Crossover_Sequence 1 | Other | Participants who meet the eligibility criteria will be randomized and will receive first the experimental product Turmipure GOLD® during the first study phase and then the placebo control during the second study phase. Both study phases are separated by a washout period of minimum 14 days. |
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| Randomized Crossover_Sequence 2 | Other | Participants who meet the eligibility criteria will be randomized and will receive first the placebo control during the first study phase and then the experimental product Turmipure GOLD® during the second study phase. Both study phases are separated by a washout period of minimum 14 days. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Turmipure Gold® | Dietary Supplement | TPG: Turmipure GOLD® - 1 capsule per day - as prescribed |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change on Perceived Muscle Soreness | Perceived Muscle Soreness in quadriceps during squatting activities assessed by VAS (0-100 mm, after two tries) | 72 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Change on Muscle damage | Muscle damage assessed by circulating levels of Creatine kinase in blood samples | 72 hours |
| Change on Isometric Muscle function recovery | Muscle function recovery assessed on quadriceps muscular function during isometric contractions recording the torque (Nm) using Biodex |
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Inclusion Criteria:
Healthy free-living males
Age: 25-45 years old
Have a BMI between 18.5 and 28 kg/m²
Moderately active with running 15-20 km per week
With 1 to 4h of training per week, with maximum 1h of lower body heavy-load or resistance training (e.g., Hill running or hiking, HIT exercise, Squats, Lunges, Leg-press, Bench steps, etc.)
Consent to the study protocol and to comply with study product
Willing to limit caffeine, smoking, and alcohol consumption during the entire study period with no more than 5 cigarettes per day and 2 drinks. Also, alcohol consumption will not be allowed 24hours prior to exercise-induced muscular damage
Willing to refrain from training for 3 days before the first test, 5 days before each damage-inducing exercise and during each supplementation phase, including active recovery exercises such as swimming, cycling at low intensity, unusual distance walking (however such should be encouraged during the 14 days wash-out)
Willing to refrain the use of anti-inflammatory/pain reliever drugs such as paracetamol, NSAIDs, etc., during each supplementation phase, from 24 hours prior to 72 hours following the exercise-induced muscular damage
Willing to refrain from 'recovery' treatments over the 72 hours following the damage inducing exercise such as:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Timothy Dinan, Professor | Atlantia Food Clinical Trials | Principal Investigator |
| Trevor Wood, PhD | Sport Physiologist University College Cork | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Atlantia Food Clinical Trials | Cork | T23 R50R | Ireland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41040018 | Derived | Schonenberger KA, Laval J, Woods T, Truillet R, Naranjo-Modad S, Mettler S, Fanca-Berthon P. A randomized, placebo-controlled, crossover clinical trial to evaluate the effect of a turmeric formulation on muscle soreness and function recovery in moderately active adults. J Int Soc Sports Nutr. 2025 Dec;22(1):2568048. doi: 10.1080/15502783.2025.2568048. Epub 2025 Oct 3. |
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| ID | Term |
|---|---|
| D063806 | Myalgia |
| D010146 | Pain |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
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| Placebo | Dietary Supplement | Placebo: colored acacia gum - 1 capsule per day - as prescribed |
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| 72 hours |
| Change on Isokinetic Muscle function recovery | Muscle function recovery assessed on quadriceps muscular function during isokinetic extensions recording the torque (Nm) using Biodex | 72 hours |
| Change on Muscle power recovery | Muscle power recovery assessed by Peak power (Watts) using vertical jump tests (best performance and average of 3 tries) | 72 hours |
| Change on Muscle ROM recovery | Muscle ROM recovery assessed by Range Of Movement using a goniometer (knee flexion) | 72 hours |
| Change on Perceived wellness and well-being | Perceived wellness and well-being is assessed by a psychometric test evaluating fatigue, sleep quality, general muscle soreness, stress, and mood (0-25, 25 indicating best feelings of wellness and well-being) | 72 hours |
| Change on Perceived exertion during exercise | Perceived exertion through breathing difficulty during exercise assessed by the Borg Rating of Perceived Exertion (0-10, 10 indicating maximal difficulty) | 30 min |
| D059352 | Musculoskeletal Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |