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The prevalence of allergy to legumes is inscreasing, especially in children and for some of these legumes, little is known and there are not included in the list of priority allergen. The overall goal of this study is to improve knowledge about fenugreek allergy. The principal aim is to evaluate the prevalence of allergy to fenugreek confirmed by a positive oral food challenge in children sensitized to fenugreek. The secondary objectives are to describe the case of allergy to fenugreek (co-allergies, severity, age..), to evaluate diagnostic values of skin prick-tests and specific IgE and to compare the molecular profile of specific IgE to peanut between sensitization to fenugreek without allergy and sensitization with a confirmed allergy
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oral Food Challenge | Diagnostic Test | diagnostic values of skin prick test and specific IgE for allergy confirmed by oral food challenge (routine, not an intervention) |
| Measure | Description | Time Frame |
|---|---|---|
| Oral food challenge to fenugreek | Astier's score 0 to 4 (0=negative, 1 and 2=mild to moderate reaction, 3 and 4 = severe reaction) | 2017-2022 |
| skin prick-test to fenugreek | skin prick test positive if wheal size superior to 3mm | 2017-2022 |
| specific IgE to fenugreek | specific IgE positive if value superior to 0.35kU/L | 2017-2022 |
| Measure | Description | Time Frame |
|---|---|---|
| severity of allergy | reactogenic dose (from 1 to 1000mg of fenugreek) | 2017-2022 |
| molecular profile for peanut allergy | IgE values for rAra h1, h2, h3, h6, h8, h9 |
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Inclusion Criteria:
Exclusion Criteria:
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children aged from 1 to 17 years old, sensitized to fenugreek with an evaluation of their tolerance to fenugreek by an oral food challenge
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Amandine Divaret-Chauveau, MD | Contact | +33 630094606 | a.chauveau@chru-nancy.fr | |
| Timé Muller, MD | Contact | +33 630336839 | t.muller@chru-nancy.fr |
| Name | Affiliation | Role |
|---|---|---|
| Amandine Divaret-Chauveau, MD | centre hospitalo-universitaire de Nancy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalo-Universitaire de Nancy | Vandœuvre-lès-Nancy | 54511 | France |
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| ID | Term |
|---|---|
| D006967 | Hypersensitivity |
| D004194 | Disease |
| ID | Term |
|---|---|
| D007154 | Immune System Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| 2017-2022 |