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To vertify the function of circulating exosomal lncRNA-GC1 on predicting and monitoring immunotherapeutic outcomes of GC
The investigator's previous work identified circulating exosomal lncRNA-GC1 as a GC-specific tumor burden marker and this novel biomarker showed promising efficiency in monitoring disease progression during treatment.
Hence in this stuty, the investigator plan to recruit a prospective cohort to support the conclusions, and provide biomarkers to realize predicting and monitoring immunotherapeutic outcomes of GC.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Circulating exosomal lncRNA-GC1 detection | Device | Collect peripheral blood sample of 80 gastric cancer patients pre-treatment. Blood samples will be transferred to central lab to detect circulating exosomal lncRNA-GC1. Tumor response evaluation will be performed after two cycles of immunotherapy by CT/MRI based on RECIST. Clinical data, including tumor stage, metastastic organ, regimen, objective response, progression free survival, overall survival, etc, will be collected according to study protocol. |
| Measure | Description | Time Frame |
|---|---|---|
| Levels of circulating exosomal lncRNA-GC1 | Circulating exosomal lncRNA-GC1 was detected by the RT-PCR followed by isolating exosomes. | Circulating exosomal lncRNA-GC1 was detected, analysis and reported at the baseline |
| Levels of circulating exosomal lncRNA-GC1 | Circulating exosomal lncRNA-GC1 was detected by the RT-PCR followed by isolating exosomes. | Circulating exosomal lncRNA-GC1 was detected, analysis and reported through study completion, average 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Survival outcomes of circulating exosomal lncRNA-GC1 | Analysis participants' survival with different levels of circulating exosomal lncRNA-GC1 detected by RT-PCR. | up to 3 years |
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Inclusion Criteria:
Exclusion Criteria:
18 Years and older
All patients in this study were enrolled by the Department of General Surgery, Chinese PLA General Hospital for conventional therapy or clinical trials
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chinese PLA General Hospital | Beijing | Beijing Municipality | 100853 | China |
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