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To vertify the function of EV-score on predicting & monitoring immunotherapeutic outcomes of GC
Our previous work identified four plasma EV-derived proteins and combined them to generate a signature score that robustly predicting immunotherapeutic outcomes at baseline and dynamically monitoring disease progressions along with the whole treatment.
Hence in this stuty, we plan to recruit a prospective cohort to support our conclusions, and provide possible method to realize predicting and monitoring immunotherapeutic outcomes of GC.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GC patients receiving immunotherapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EV-array | Device | Collect peripheral blood sample of 40 gastric cancer patients pre-treatment. Blood samples will be transferred to central lab to detect EV-score by EV-array. Tumor response evaluation will be performed after two cycles of chemotherapy by CT/MRI based on RECIST. Clinical data, including tumor stage, metastastic organ, regimen, objective response, progression free survival, overall survival, etc, will be collected according to study protocol. |
| Measure | Description | Time Frame |
|---|---|---|
| EV-Score | EV-Score was calculated by the expression level of four tumor-associated proteins on plasma EV | EV-Score was detected, analysis and reported at the baseline of the treatment. |
| Measure | Description | Time Frame |
|---|---|---|
| Survival significance of EV-Score | Analysis patients' survival with different EV-Score. | up to 3 years |
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Inclusion Criteria:
Exclusion Criteria:
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All patients in this study were enrolled by the Department of gastrointestinal oncology, Peking University Cancer Hospital & Institute for conventional therapy or clinical trials
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University Cancer Hospital & Institute | Recruiting | Beijing | China |
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