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The study will investigate the effect of pharmacological preventive treatment, education, physiotherapy and psychological counselling on the headache and associated symptoms in patients refered to the Danish Headache Center
Pharmacological interventions are candesartan, amitritylin and gabapentin depending on the headache phenotype. In total 3 visits spanned over 1 year
Education is conducted as group sessions of up to 10 patients by two specialist nurses 2 x 90 min Physiotherapy is conducted as group sessions of up to 5 patients by physiotherapists 8 x 60 min plus 2 individual sessions.
Psychology is conducted as group sessions of up to 10 patients by psychologist 3x60 min plus option of 1 individual session.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Candesartan | Drug | Multdisciplinary approach |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in headache days | Headache days will be obtained via a validated questionaire | 1 year |
| Rivermead post-concussion questionare score | Rivermead is a validated questionaire to assess concussion symptoms | 1 year |
| HADS-scores | HADS = Hospital anxiety and depression scale. A validated tool to assesss depression and anxiety symptoms | 1 year |
| Self-perceived health | based on EU-SILC validated question on self-perceived health ('How is your health in general?'), which contains five answering categories; 1) very good, 2) good, 3) fair, 4) bad, 5) very bad. | 1 year |
| Level of physical activity | Based on questionaire, where patients can choose: Low level of physical activity: primarily sedentary activities or light exercise at least 4 hours a week, or | 1 year |
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Inclusion Criteria:
Patients with post-traumatic headache
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Exclusion Criteria:
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All patients with a head trauma as a cause of the headache will be included in the study
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Danish Headache Center | Glostrup Municipality | 2600 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41761605 | Derived | Wasfi Abd-Albaqi S, Kjeldgaard Madsen B, Salomon SM, Caspersen N, Kroll LS, Larsen K, Danielsen T, Thomsen ST, Gaj Baatz SR, Mose LS, Amin FM, Schytz HW. The effect of multidisciplinary open-label treatment in patients with persistent post-traumatic headache at two tertiary headache centers. Pain Manag. 2026 May;16(5):471-478. doi: 10.1080/17581869.2026.2638405. Epub 2026 Feb 27. |
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| ID | Term |
|---|---|
| D051298 | Post-Traumatic Headache |
| D038223 | Post-Concussion Syndrome |
| ID | Term |
|---|---|
| D051271 | Headache Disorders, Secondary |
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| C081643 | candesartan |
| D000639 | Amitriptyline |
| D000077206 | Gabapentin |
| ID | Term |
|---|---|
| D003986 | Dibenzocycloheptenes |
| D001567 | Benzocycloheptenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D006841 | Hydrocarbons, Aromatic |
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| D009422 | Nervous System Diseases |
| D001924 | Brain Concussion |
| D016489 | Head Injuries, Closed |
| D006259 | Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D014949 | Wounds, Nonpenetrating |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D011083 | Polycyclic Compounds |
| D000588 | Amines |
| D005680 | gamma-Aminobutyric Acid |
| D000613 | Aminobutyrates |
| D002087 | Butyrates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D003509 | Cyclohexanecarboxylic Acids |
| D000146 | Acids, Carbocyclic |
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |