decipher the role of microbiota in glycemic response change after bariatric surgery

Despite the vast knowledge linking the gut microbiome to metabolism and the glucose response, the relation still remains unclear. hopefully, a deep understanding of the mechanisms underlying metabolic improvement following bariatric surgery will make it possible to identify targets for pharmacological intervention, which will reduce the need for surgery and its risks.

Previous studies have characterized the microbiome after bariatric surgery, but most suffer from methodological limitations.

The current study has the potential to be innovative and make a significant contribution to understanding the mechanisms involved in early metabolic improvement after bariatric surgery.

Inclusion Criteria:

• candidates of bariatric surgery or cholecystectomy
• age 18-70
• male/female

Exclusion Criteria:

• previous bariatric surgery
• type 1 diabetes
• antibiotic treatment 3 months prior to the study
• probiotic treatment 3 months prior to the study
• chronic disease - gastrointestinal disease, malignancy, psychiatric disorder, endocrinologic disorders
• any pathologic findings during endoscopy
• participants who will suffer from a post-operation complication

patients arriving at the outpatient unit at Tel Aviv Sourasky medical center