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In this study, the investigators compared the improvement of liver reserve function related indicators in patients with liver cirrhosis after laparoscopic splenectomy and azygoportal disconnection. To determine whether surgical treatment can help enhance postoperative liver reserve function and improve patient prognosis.
The patients were enrolled according to the research criteria, and collected the general basic information of the patients. After the preoperative preparation was perfected, the same surgical team performed laparoscopic splenectomy and azygoportal disconnection, and the same nursing team performed the nursing after the operation. Then, patients received a unified treatment plan after surgery, including medication, other treatments and follow-up. During the treatment, the liver reserve function related indicators of the patients were monitored before surgery, 3, 6, 12 and 24 months after surgery, including TBIL, DBIL, ALB, ALT, INR, PT, Child-Pugh, ascites, prealbumin, ICG-K, ICG-R 15 and ICG-T/2.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental Group | Experimental | Laparoscopic splenectomy and azygoportal disconnection |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laparoscopic splenectomy and azygoportal disconnection | Procedure | The laparoscopic splenectomy and azygoportal disconnection was performed by the same surgical team. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Liver reserve function ICG-K at 3 months after surgery. | The level of liver reserve function ICG-K at 3 months after surgery. | 3 months |
| Liver reserve function ICG-K at 6 months after surgery. | The level of liver reserve function ICG-K at 6 months after surgery. | 6 months |
| Liver reserve function ICG-K at 12 months after surgery. | The level of liver reserve function ICG-K at 12 months after surgery. | 12 months |
| Liver reserve function ICG-K at 24 months after surgery. | The level of liver reserve function ICG-K at 24 months after surgery. | 24 months |
| Liver reserve function ICG-R 15 at 3 months after surgery. | The level of liver reserve function ICG-R 15 at 3 months after surgery. | 3 months |
| Liver reserve function ICG-R 15 at 6 months after surgery. | The level of liver reserve function ICG-R 15 at 6 months after surgery. | 6 months |
| Liver reserve function ICG-R 15 at 12 months after surgery. | The level of liver reserve function ICG-R 15 at 12 months after surgery. | 12 months |
| Liver reserve function ICG-R 15 at 24 months after surgery. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guo-Qing Jiang, MD | Contact | +8651487373272 | jgqing2003@hotmail.com | |
| Dou-Sheng Bai, MD | Contact | +8651487373372 | bdsno1@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Guo-Qing Jiang, MD | Clinical Medical College of Yangzhou University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinical Medical College of Yangzhou University | Recruiting | Yangzhou | Jiangsu | 225001 | China |
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The level of liver reserve function ICG-R 15 at 24 months after surgery. |
| 24 months |
| Liver reserve function ICG-T/2 at 3 months after surgery. | The level of liver reserve function ICG-T/2 at 3 months after surgery. | 3 months |
| Liver reserve function ICG-T/2 at 6 months after surgery. | The level of liver reserve function ICG-T/2 at 6 months after surgery. | 6 months |
| Liver reserve function ICG-T/2 at 12 months after surgery. | The level of liver reserve function ICG-T/2 at 12 months after surgery. | 12 months |
| Liver reserve function ICG-T/2 at 24 months after surgery. | The level of liver reserve function ICG-T/2 at 24 months after surgery. | 24 months |
| ID | Term |
|---|---|
| D008103 | Liver Cirrhosis |
| D006975 | Hypertension, Portal |
| D005355 | Fibrosis |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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