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This project is designed to develop and evaluate an Internet-based exercise intervention (tai ji quan Moving to Improve Brain Health) using real-time videoconferencing for older adults with mild cognitive impairment (MCI).
The project has three major goals: (a) transforming an in-person tai ji quan brain health intervention protocol into an online (virtual) class protocol and evaluating its feasibility of implementation in older adults with MCI, (b) developing and evaluating online assessment and data ascertainment procedures that encompass cognitive and physical performance measures, and (c) conducting a randomized controlled trial comparing the effectiveness of this new online intervention protocol with a conventional stretching exercise group in older adults with MCI.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cognitively enhanced tai ji quan | Experimental | Participants receive a cognitively enhanced tai ji quan exercise intervention for 16 weeks. |
|
| stretching exercise | Active Comparator | Participants receive a stretching exercise intervention for 16 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tai ji quan | Behavioral | cognitively enhanced tai ji quan exercise |
| |
| Measure | Description | Time Frame |
|---|---|---|
| (a) Total number of intervention sessions taught by instructors over the course of study (recorded by a class check sheet) and (b) total number of classes attended by participants over the course of intervention as recorded by class attendance sheet | assess the extent to which interventionists successfully implement the prespecified exercise training protocol. | 16 weeks |
| number of dropouts from the intervention and study as assessed by a study recording sheet | assess intervention dropout rate and retention rate | 16 weeks |
| Number of participants expressing intervention program satisfaction as assessed by a self-report survey | assess the program acceptability among tai ji quan participants | 16 weeks |
| Change in global cognitive function assessed by Montreal Cognitive Assessment | assess change from baseline cognitive function at 16 weeks | baseline, 16 weeks |
| Change in attention and working memory as assessed by Digit Span - forward and backward | assess change from baseline in attention and working memory at 16 weeks | baseline, 16 weeks |
| Change in dual-task cost as assessed by Timed Up and Go with a cognitive task | assess change from baseline in the ability to stand up from a chair, walk, and sit down while performing an arithmetic task at 16 weeks | baseline, 16 weeks |
| Change in executive function as assessed by Trail Making B |
| Measure | Description | Time Frame |
|---|---|---|
| Change in depression as assessed by Geriatric Depression scale | assess change from baseline in the level of depression at 16 weeks | baseline, 16 weeks |
| Change in physical activity as assessed by International Physical Activity Questionnaire |
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Inclusion criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Fuzhong Li, Ph.D. | Oregon Research Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oregon Research Institute | Eugene | Oregon | 97403 | United States |
There is a plan to make IPD and related data dictionaries available.
12 months after the completion of the study.
The de-identified data that support the findings of this study are available from the corresponding author upon reasonable request. Restrictions may apply to preserve participant confidentiality.
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Oct 10, 2025 | |
| Reset | Oct 23, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Oct 10, 2025 | Oct 23, 2025 |
| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D026302 | Tai Ji |
| ID | Term |
|---|---|
| D026441 | Mind-Body Therapies |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D026241 | Exercise Movement Techniques |
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| Stretching |
| Behavioral |
Stretching exercise |
|
assess change from baseline executive function at 16 weeks |
| baseline, 16 weeks |
| Change in executive function as assessed by Category Fluency for Animals | assess change from baseline executive function at 16 weeks | baseline, 16 weeks |
| Change in cognitive functioning assessed by Everyday Cognition | assess change from baseline cognitive functioning at 16 weeks | baseline, 16 weeks |
| Change in physical performance as measured by Timed Up and Go test | assess change from baseline in the ability to stand up from a chair, walk, and sit down at 16 weeks | baseline, 16 weeks |
| change in leg strength as assessed by 30-second chair stand test | assess change from baseline in leg strength at 16 weeks | baseline, 16 weeks |
| Change in balance using a 4-stage balance test | assess change from baseline in balance at 16 weeks | baseline, 16 weeks |
assess change from baseline in physical activity at 16 weeks
| baseline, 16 weeks |
| Change in quality of life as assessed by EuroQol (EQ-5D-3L) | assess change from baseline in quality of life at 16 weeks | baseline, 16 weeks |
| D026741 |
| Physical Therapy Modalities |