Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Stroke is of high morbidity and mortality, and surviving patients are often unable to take care of themselves because of severe motor dysfunction. The brain has plasticity, and makes adaptive changes after stroke, resulting in the reorganization and compensation of neural networks. However, the muscle tone of some patients will significantly increase during the recovery process, which affects the rehabilitation effect. Neuromodulation techniques such as repetitive transcranial magnetic stimulation (rTMS) have been widely used to promote brain network remodeling after stroke. The investigators attempted to evaluate the motor brain network characteristics of spastic patients by fNIRS, and used the most active brain regions as rTMS stimulation regions to evaluate the improvement effect of this individualized treatment on post-stroke spasticity.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Individualized rTMS based on fNIRS | Experimental | Low-frequency rTMS will be given to the most active brain regions assessed by fNIRS. |
|
| Traditional rTMS strategy | Active Comparator | The control group will always be given low-frequency rTMS to contralesional M1 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| individual rTMS based on fNIRS | Procedure | The rTMS parameters will be set according to fNIRS results. |
|
| Measure | Description | Time Frame |
|---|---|---|
| modified Ashworth scale | The range is 0-â…£ level, the higher the level, the higher the spasticity. | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Fugl-Meyer Assessment of upper limb motor function | The score range is 0-66 points, the higher the score, the better the motor function of upper limb. | 1 month |
| Barthel index | The score range is 0-100 points, the higher the score, the better the activities of daily living. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ziwen Yuan, MD | Contact | +8617502991129 | yuanziwen@xjtufh.edu.cn |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| First Affiliated Hospital of Xi'an Jiaotong University | Recruiting | Xi'an | Shaanxi | 710000 | China |
Not provided
| ID | Term |
|---|---|
| D020521 | Stroke |
| D009128 | Muscle Spasticity |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Traditional rTMS strategy | Procedure | The low-frequency rTMS to contralesional M1 will always be used. |
|
| 1 month |
| average weighted clustering coefficient | This is a brain network indicator based on graph theory. It is a measure of the local separation of the graph. The higher the average weighted clustering coefficient, the higher the degree of segregation of the brain network. | 1 month |
| global efficiency | This is a brain network indicator based on graph theory. It is a measure of the local integration of the graph. The higher the global efficiency, the stronger the ability of the network to transmit information. | 1 month |
| inter-density | It is a brain network indicator based on graph theory and is defined as the ratio of the actual number of connections among all possible connections between bilateral hemispheres. | 1 month |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D009122 | Muscle Hypertonia |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |