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This study aimed to aim to investigate the efficacy of individualized rTMS according to lateralization index on motor recovery and cortical excitability in subacute stroke patients.
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technology.
High and low frequencies of rTMS could modulate the excitability of the cerebral cortex. Theta burst stimulation (TBS) has achieved a similar effect to traditional rTMS mode.
However, the current rTMS studies for stroke patients utilized the same therapeutic protocol and there is no individualized rTMS protocol based on the value of lateralization index.
This study aimed to aim to investigate the efficacy of individualized rTMS according to lateralization index on motor recovery and cortical excitability in subacute stroke patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| individualized rTMS | Experimental | Patients will receive individualized repetitive transcranial magnetic stimulation according to lateralization index measured by functional near-infrared spectroscopy |
|
| Traditional rTMS | Active Comparator | Control group is given traditional rTMS |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Repetitive transcranial magnetic stimulation | Device | Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technology. High and low frequencies of rTMS could modulate the excitability of the cerebral cortex. |
| Measure | Description | Time Frame |
|---|---|---|
| Fugl-Meyer Assessment | Fugl-Meyer Assessment motor function set, score: 0-66, higher scores indicate a better outcome. | 12 weeks post intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Medical Research Council (MRC) Scale for Muscle Strength | Medical Research Council (MRC) Scale for Muscle Strength, assessing muscle strength from Grade 5 (normal) to Grade 0 (no visible contraction). | 1 week, 4 weeks, 12 weeks post intervention |
| National Institutes of Health Stroke Scale |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Meng Ting Lin, M.D. | Contact | +886-2312-3456 | 67048 | b96401093@ntu.edu.tw |
| Yan Ci Liu, PhD | Contact | +886233668135 | yanciliu@ntu.edu.tw |
| Name | Affiliation | Role |
|---|---|---|
| Meng Ting Lin, M.D. | The Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan University Hospital | Recruiting | Taipei County | Taipei | 100 | Taiwan |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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National Institutes of Health Stroke Scale, The maximum possible score is 42, with the minimum score being a 0. Higher scores indicate a worse outcome. |
| 1 week, 4 weeks, 12 weeks post intervention |
| Barthel Index | Barthel Index, score 100-0. Higher scores indicate a better outcome. | 1 week, 4 weeks, 12 weeks post intervention |
| Modified Rankin Scale | Modified Rankin Scale, score from 0 to 6. Higher scores indicate a worse outcome. | 1 week, 4 weeks, 12 weeks post intervention |
| MEP | motor evoked potential | 1 week, 4 weeks, 12 weeks post intervention |
| Fugl-Meyer Assessment | Fugl-Meyer Assessment motor function set, score: 0-66, higher scores indicate a better outcome. | 1 week, 4 weeks post intervention |
| functional NIRS | Functional Near Infrared Spectroscopy to detect the cortical excitability | 1 week, 4 weeks, 12 weeks post intervention |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |