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The aim of this single center, single arm and prospective study is to explore the safety and efficacy of tumor antigen-pulsed DC vaccine( OCDC and NeoDC) for postoperative adjuvant treatment of ESCC
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental Group | Experimental | Autologous DCs pulsed with HOCl-oxidized autologous tumor lysate (OCDC) vaccine is administered in prime phase and personal neoantigen-sensitized DC(NeoDC) vaccine is administered in boost phase. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| OCDC vaccine; NeoDC vaccine | Biological | OCDC vaccine and NeoDC vaccine are administered in a prime-boost regimen by subcutaneous injection. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The number of treatment-related adverse events | Number of participants with treatment-related adverse events as assessed by CTCAE v4.0 | From the first administration of vaccine to 3 months after the last administration |
| Measure | Description | Time Frame |
|---|---|---|
| Disease-free Survival | Number of participants with Disease-free Survival as assessed by RECIST1.1 | from the study start to 1 year after the study completion |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhen-Yu Ding, Prof | Contact | 0086288542357 | dingzhenyu@scu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Zhen-Yu Ding, Prof | Sichuan University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| West China Hospital | Chengdu | Sichuan | 610000 | China |
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| ID | Term |
|---|---|
| D000077277 | Esophageal Squamous Cell Carcinoma |
| D004938 | Esophageal Neoplasms |
| ID | Term |
|---|---|
| D002294 | Carcinoma, Squamous Cell |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
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| D009369 | Neoplasms |
| D018307 | Neoplasms, Squamous Cell |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D006258 | Head and Neck Neoplasms |
| D004066 | Digestive System Diseases |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |