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The aim of this single center, single arm and prospective study is to explore the safety and efficacy of tumor antigen-sensitized DC vaccine in postoperative adjuvant treatment of esophageal cancer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tumor antigen-sensitized DC vaccine | Experimental | Tumor antigen-sensitized vaccine is administrated, 1-week interval, totally 2 times. 2-week later, Neo-antigen DC vaccine is administrated, 2-week interval, totally 5 times. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tumor antigen-sensitized DC vaccine | Biological | subcutaneous administration |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with treatment-related adverse events as events as assessed by CTCAE v4.0 | Number of participants with treatment-related adverse events as events as assessed by CTCAE v4.0 | 3 months after the last administration of cells |
| Measure | Description | Time Frame |
|---|---|---|
| Disease-free Survival | Number of participants with Disease-free Survival as assessed by RECIST1.1 | through study completion, an average of 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Zhen-Yu Ding, Prof | Sichuan University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| West China Hospital | Chengdu | Sichuan | 610000 | China |
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| ID | Term |
|---|---|
| D002277 | Carcinoma |
| D004938 | Esophageal Neoplasms |
| ID | Term |
|---|---|
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
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| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D006258 | Head and Neck Neoplasms |
| D004066 | Digestive System Diseases |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |