Comparison of Antimicrobial Action of Sodium Hypochlorite and Polyhexamethylene Biguanide as Root Canal Irrigants

Comparison of Antimicrobial Action of Sodium Hypochlorite and Polyhexamethylene Biguanide as Root Canal Irrigants in Patients Reporting With Non-vital Necrotic Pulp and Apical Periodontitis

The aim of this randomized clinical trial is to compare the antibacterial effects of sodium hypochlorite (NaOCl) and Polyhexamethylene biguanide during root canal treatment .

This study will compare the antibacterial effectiveness of sodium hypochlorite and PHMB, to find out whether PHMB can be used as a substitute to NaOCL. Polyhexamethylene biguanide (PHMB), is a disinfectant solution having a broad spectrum of antimicrobial activity and is investigated as an endodontic irrigant. It is non-corrosive, non-toxic and acts by disrupting cell membrane integrity.

Inclusion Criteria:

• • Patients aged 18 to 50 years

  • Both male and female patients
  • Periodontally healthy teeth as determined by Periodontal Probing
  • Patients with non-vital necrotic pulps as determined by Cold Test
  • Patients with acute apical periodontitis determined by history and clinical examination
  • Clinical Findings:

Visual: Carious tooth decay Occlusion: Hyperocclusion Pulp vitality test: Negative Periapical radiograph: Caries involving pulp space and PDL widening Percussion Test: Positive Palpation Test: Negative

• Single rooted teeth as determined radiographically

Exclusion Criteria:

• • Multirooted teeth

  • Teeth undergoing Re-endo treatments
  • Teeth with root fractures and/ non restorable determined by clinical and radiographic examination
  • Patients receiving antibiotic treatment in the past 3 months determined by history
  • Patient with Diabetes determined by history
  • Patient with history of smoking