Stem Cells and Stromal Vascular Fraction for Temporomandibular Joint Disease

Stem Cells Transplantation for Temporomandibular Joint Disease: Phase I/II Study

It will be evaluate the safety of mesenchymal stem cells and adipose tissue derived stromal vascular fraction (SVF) in temporomandibular joint disease cases.

umbilical cord derived mesenchymal stem cells produced under GMP facility in Erciyes University and SVF produced in operation theatre.

Inclusion Criteria:

• Chronic temporomandibular arthritic disorder
• History of pain and joint noises for at least 3 months
• Must have more than VAS 5 TMJ pain
• must have internal derangement of TMJ
• Limited mouth opening
• Magnetic resonance imaging evidence of effusion or degeneration
• Already treated with conservative methods (occlusal splint,pharmacological and/or physio-kinesio therapy) without satisfactory benefit.

Exclusion Criteria:

• Cancer patients
• Immunosupressed patients
• Previous TMJ traumas and fractures
• Previous TMJ surgeries
• TMJ ankylosis