Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
It will be evaluate the safety of mesenchymal stem cells and adipose tissue derived stromal vascular fraction (SVF) in temporomandibular joint disease cases.
umbilical cord derived mesenchymal stem cells produced under GMP facility in Erciyes University and SVF produced in operation theatre.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| umbilical cord derived mesenchymal stem cells transplantation group | Experimental | taking umbilical cord derived mesenchymal stem cells |
|
| stromal vascular fraction cells application group | Experimental | taking stromal vascular fraction cells |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Stem Cells | Biological | ATMP |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline Pain at 15th day | using by Visual Analogue Scale (VAS); higher scores mean worse outcome | 15th day |
| Change from baseline maximum mouth opening at 15th day | the distance between incisal edge of maxillary central incisor to the incisal edge of mandibular central incisor, when the mouth is opened as wide as possible painlessly | 15th day |
| Change from baseline maximum mouth opening at 1 month | the distance between incisal edge of maxillary central incisor to the incisal edge of mandibular central incisor, when the mouth is opened as wide as possible painlessly at first month; higher scores means a better outcome | 1. month |
| Change from baseline maximum mouth opening at 3 months | the distance between incisal edge of maxillary central incisor to the incisal edge of mandibular central incisor, when the mouth is opened as wide as possible painlessly at third month; higher scores means a better outcome | 3. month |
| Change from baseline maximum mouth opening at 6 months | the distance between incisal edge of maxillary central incisor to the incisal edge of mandibular central incisor, when the mouth is opened as wide as possible painlessly at 6th month,higher scores means a better outcome | 6. month |
| Change from baseline pain at 1 month | using by Visual Analogue Scale (VAS) | 1. month |
| Change from baseline pain at 3 month |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline 'comfort ' at 6th month | using by Visual Analogue Scale (VAS); higher scores mean better outcome | 6 months |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zeynep B Gonen, DDS,PHD | Contact | 00903522076666 | 13602 | zburcin@gmail.com |
| Genkok center | Contact |
| Name | Affiliation | Role |
|---|---|---|
| Zeynep B Gonen, DDS,PHD | Assoc.Prof | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Erciyes University | Recruiting | Kayseri | 38039 | Turkey (Türkiye) |
Not provided
Not provided
Not provided
Not provided
Not provided
using by Visual Analogue Scale (VAS) |
| 3. month |
| Change from baseline pain at 6 month | using by Visual Analogue Scale (VAS) higher scores mean worse outcome | 6. month |
| ID | Term |
|---|---|
| D013705 | Temporomandibular Joint Disorders |
| ID | Term |
|---|---|
| D017271 | Craniomandibular Disorders |
| D008336 | Mandibular Diseases |
| D007571 | Jaw Diseases |
| D009140 | Musculoskeletal Diseases |
| D007592 | Joint Diseases |
| D009135 | Muscular Diseases |
| D009057 | Stomatognathic Diseases |
Not provided
Not provided