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Arthrocentesis of TMJ then injection of micro fragmented adipose tissue mixed with bone marrow aspirate on healing of TMJ internal disc derangement without reduction.
Arthrocentesis of TMJ then injection of intra and periarticular of 2 mm of micro fragmented adipose tissue mixed with Bone marrow aspirate extracted from 20 mm of bone marrow using gradient separation method in one group and use of Bone marrow aspirate injection only in another group and injection of intra and periarticular of 2 mm hyaluronic acid gel in control group on healing of TMJ internal disc derangement without reduction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Micro fragmented adipose tissue | Active Comparator | Micro fragmented adipose tissue mixed with Bone marrow stem cells injection on healing of TMJ internal disc derangement without reduction |
|
| Bone marrow stem cells aspiration | Active Comparator | Bone marrow stem cells injection on healing of TMJ internal disc derangement without reduction |
|
| hyaluronic acid gel injection | Placebo Comparator | Intra and periarticular injection of 2 mm of hyaluronic acid gel on healing of TMJ internal disc derangement without reduction |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Micro fragmented adipose tissue mixed with bone marrow stem cells | Procedure | mixture of stem cells |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mandibular mouth opening | Measuring Maximum interincisal opening measured by plastic scale ruler in millimeter | 6 Months |
| Measure | Description | Time Frame |
|---|---|---|
| Post-operative pain | measuring pain by using visual analogue scale from (0 to 10) score where zero indicate no pain and 10 indicate worst pain | six months follow-up |
| Joint sound | Clicking by clinical examination indicate ( present or absent ) of clicking |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo university | Cairo | Egypt |
|
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| Bone Marrow stem cells aspirate | Procedure | stem cells |
|
| six months follow-up |
| Lateral and protrusive movements | Measuring lateral and protrusive movements by using range of motion scale in millimeter | six months follow-up |
| Mohamed Talaat Abbas Hassan | Cairo | Egypt |
|
| ID | Term |
|---|---|
| D013705 | Temporomandibular Joint Disorders |
| ID | Term |
|---|---|
| D017271 | Craniomandibular Disorders |
| D008336 | Mandibular Diseases |
| D007571 | Jaw Diseases |
| D009140 | Musculoskeletal Diseases |
| D007592 | Joint Diseases |
| D009135 | Muscular Diseases |
| D009057 | Stomatognathic Diseases |
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