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The Sentinel-001 study aims to identify a combination of biomarkers suitable for triage of breathlessness.

Inclusion Criteria:

• Aged 18-90 years.
• Has experienced episode of breathlessness during the past 12 months triggering interaction with a health care professional. Self-reported breathlessness using any of the following words to describe symptoms will qualify as a presentation of breathlessness regardless of aetiology or severity of symptoms: shortness of breath, tight chest, trouble breathing, breathlessness, dyspnoeic, breathless, asthmatic, suffocating, wheezing, fighting for breath or any equivalent word. Breathlessness does not have to be the primary presenting symptom.
• Deemed clinically sufficiently stable to participate according to health care practitioner.

Exclusion Criteria:

• Inability to understand written local language at a year 5 level.
• Not being confident in use of digital technology (smartphone and/or tablet). This will become evident through an inability to use the system.
• Inability to enter required study sample data due to diminished consciousness and/or physical or mental capacity regardless of whether this is associated with the breathlessness event.
• Received an investigational medical product in the context of a Clinical Trial during the 28 days prior to first probe administration.

Participants having experienced episode of breathlessness during the past 12 months triggering interaction with a health care professional.