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The purpose of this study is to evaluate the capacity of some novels biomarkers Procalcitonin (PCT), Midregional Proadrenomedullin (MR pro ADM), Midregional pro-atrial natriuretic peptide (MR pro ANP), Copeptin (CT pro arginine vasopressin), Pro endothelin to stratify the risk in severe dyspnea.
In emergency department shortness of breath (SOB)is a common symptom and its cause is not easy to be identified. The risk stratifying remains a challenge, Prognostic value of biomarkers might be helpful.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute dyspnea in ED | Acute severe shortness of breath (SOB) in emergency Department (ED) with suspicion of acute heart failure (AHF) or Pulmonary Embolism (PE)or Community-acquired pneumonia (CAP) or acute Exacerbation of chronic obstructive pulmonary disease (AE COPD) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Prognostic value of Biomarkers | Other | Mr pro ADM, Mr pro ANP, PCT, Copeptin and pro endothelin value to stratify the risk in SOB patients |
|
| Measure | Description | Time Frame |
|---|---|---|
| prognostic value of PCT, MR proADM, Mr pro ANP, Copeptin and pro endothelin in SOB | all cause mortality or Intensive Care Unit(ICU) admission from inclusion to Day 30 | at Day 30 |
| Measure | Description | Time Frame |
|---|---|---|
| establish the diagnostic value of PCT and MR pro ANP | Confirm the diagnostic value of PCT and it's level in sepsis and MR pro ANP in Heart failure | at admission |
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Inclusion Criteria:
Exclusion Criteria:
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Severe acute SOB Suspicion of CAP, Acute Heart failure, AE COPD or PE
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| Name | Affiliation | Role |
|---|---|---|
| Pierre Hausfater, Pr | ED Pitié SalpêtrièreHospital in Paris | Study Chair |
| Yann-Erick Claessens, Dr | ED Cochin Hospital in Paris | Principal Investigator |
| Guillaume Der Sahakian, Dr | ED Hotel Dieu Hospital in Paris | Principal Investigator |
| Arnaud Martinage, Dr | ED Hotel Dieu Hospital in Nantes | Principal Investigator |
| Fatima Rayeh, Dr | ED La Miletrie Hospital in Poitiers | Principal Investigator |
| Eric Weil, Pr | ED Hospital B in Lille | Principal Investigator |
| Luc-Marie JOLY, Dr | ED Charles Nicolle Hospital in Rouen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Emergency department of Pitié Salpetriere Hospital | Paris | Paris | 75013 | France |
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| ID | Term |
|---|---|
| D004417 | Dyspnea |
| D011655 | Pulmonary Embolism |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
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plasma
| D013568 | Pathological Conditions, Signs and Symptoms |
| D008171 | Lung Diseases |
| D004617 | Embolism |
| D016769 | Embolism and Thrombosis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |