Characterization of Rhythmicity Profiles of Bradykinin-mediated Angioedema Attacks Using a Tracking Smartphone Application.

Rhythmicity Profiles of Bradykinin-mediated Angioedema.

Bradykinin-mediated angioedema is a rare and disabling disease, characterized by the occurrence of attacks marked by localized swelling of skin, but also of the airways, which can be life-threatening. The unpredictable nature of attacks is a key feature of angioedema, placing patients under constant threat. It seems that there are different patterns of yearly distribution for these attacks, but this is poorly described in the literature. The objectives of the study are to establish different rhythmicity profiles of patients according to the frequency of the attacks; and to identify factors potentially triggering the attacks. For this purpose, patients with bradykinin-mediated angioedema will be monitored daily using a smartphone application. Each day, the application will ask the patient if he or she is having an attack and, if so, the characteristics of the attack and the events preceding it

Inclusion Criteria:

• Diagnosis of bradykinin-mediated angioedema
• Age > 18
• Having a smartphone
• Non opposition to answer the questionnaire

Exclusion Criteria:

• Patients with other type (histaminergic) angioedema
• Patient unable or unwilling to use a smartphone application
• Opposition to the research
• Minor or protected adult
• Person deprived of liberty