The objective is to compare the gene expression of B1 and / or B2 monocyte receptors between patients with hereditary bradykinetic angioedema and control subjects.

Inclusion Criteria (patients):

• Patient with inherited bradykinic angioedema due to quantitative or qualitative C1-inhibitor deficiencies, regardless of the frequency or severity of seizures and regardless of their background treatment, with the following diagnostic criteria:

  • C1-inhibitor rate <50% of normal
  • Repeated episodes characteristic of bradykinic angioedema
  • Hereditary nature of the disease.

• Person who read and understood the newsletter and signed the consent form

• Person affiliated with a social security scheme

• Effective contraception in women of childbearing age (negative pregnancy test). For postmenopausal women, a confirmatory diagnosis should be obtained (amenorrhea for at least 12 months before the inclusion visit).

Inclusion Criteria (volunteers):

• Person affiliated with a social security scheme
• Person who read and understood the newsletter and signed the consent form
• Effective contraception in women of childbearing age (negative pregnancy test). For postmenopausal women, a confirmation diagnosis should be obtained (amenorrhea for at least 12 months before the inclusion visit)

Exclusion Criteria (patients):

• Angioedema crisis less than 1 month old

• Chronic inflammatory disease such as rheumatoid arthritis or Crohn's disease.

• Acute infection in progress, with or without anti-infectious treatment

• Contraindication to the use of trinitrin:

  • Hypersensitivity to nitrates or to any of the excipients
  • shock, severe hypotension,
  • obstructive cardiomyopathy,
  • inferior court inferior myocardial infarction with right ventricular extension, except in case of evidence of left ventricular failure,
  • intracranial hypertension,
  • patient treated with sildenafil

• Pregnant or parturient or breastfeeding woman or lack of proven contraception

• Person deprived of liberty by an administrative or judicial decision or person placed under the protection of justice / sub-tutorship or curatorship

• Patient participating or having participated in another therapeutic trial within one week.

Exclusion Criteria (volunteers)

• Chronic inflammatory disease such as rheumatoid arthritis or Crohn's disease.

• Acute infection in progress, with or without anti-infectious treatment

• Contraindication to the use of trinitrin:

  • Hypersensitivity to nitrates or to any of the excipients
  • shock, severe hypotension,
  • obstructive cardiomyopathy,
  • inferior court inferior myocardial infarction with right ventricular extension, except in case of evidence of left ventricular failure,
  • intracranial hypertension,
  • patient treated with sildenafil

• Pregnant or parturient or breastfeeding woman or lack of proven contraception

• Person deprived of liberty by an administrative or judicial decision or person placed under the protection of justice / sub-tutorship or curatorship

• Person participating or having participated in another therapeutic trial within one week.