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A follow up study of adult patients who have been treated in the ICU at Mölndal hospital due to Covid19 in the period of 2020 to 2022.
The spread of Covid19 in the population in Sweden from 2019 and onwards posed new and serious strain on our ICU capacity. The disease presented with initially influenza like symptoms and evolved into multiorgan failure. 5% of all patients with verified Covid 19 were in need of critical care and among them the in-hospital mortality rate was 20%.
Patients will be followed up with after a minimum of three months after discharge from the ICU with regards to organ function.
Examinations within the scope of the study are;
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Post ICU covid survivors | Patients having survived and discharged from ICU care as a result of Covid 19 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Follow up | Other | Comprehensive follow up in dedicated follow up unit |
|
| Measure | Description | Time Frame |
|---|---|---|
| Lung Function oxygen saturation | Respiratory function following Covid19, saturation in SaO2% | One year |
| Lung Function, end tidal Co2 in kPa | Respiratory function following Covid19, end tidal carbon dioxide in kPa, | One year |
| Lung Function, complete arterial and venous blood gas in kPa | Respiratory function with arterial and venous blood gas pO2 and pCO2 in kPa | One year |
| Lung Function spirometry | Respiratory function with spirometry in Volumes in ml related to BMI | One year |
| Lung parenchym status | Ct scan of the lungs, assessed by radiology specialist, assessed for fibrosis, bronchiectasia and residual ground glass abnormalities | One year |
| ECG | 5 lead ECG for the detection av arrythmia | One year |
| Cardiac ultrasound | Cardiac ultrasound including ejection fractions (EF%) | One year |
| Cardiac biomarkers Troponin in ng/L | Cardiac function Blood sampling | One year |
| Measure | Description | Time Frame |
|---|---|---|
| Return to work | Are the subjects working or at the disposal of the labour market | One year |
| Return to own home | Are the subjects living in their original housing or equivalent? |
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Inclusion Criteria:
Exclusion Criteria:
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All patients that have been treated for Covid 19 at the ICU at Mölndal are eligible for participation
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sahlgrenska University Hospital | Mölndal | Västra Götaland County | 431 80 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32071063 | Background | Mahase E. Coronavirus covid-19 has killed more people than SARS and MERS combined, despite lower case fatality rate. BMJ. 2020 Feb 18;368:m641. doi: 10.1136/bmj.m641. No abstract available. | |
| 32236644 | Background | Pan XW, Xu D, Zhang H, Zhou W, Wang LH, Cui XG. Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis. Intensive Care Med. 2020 Jun;46(6):1114-1116. doi: 10.1007/s00134-020-06026-1. Epub 2020 Mar 31. No abstract available. |
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Due to small sample size, anonymity will be difficult if data is shared
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| D003693 | Delirium |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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Blood samples
| Cardiac biomarkers NTproBNPin ng/L | Cardiac function Blood sampling | One year |
| Cognitive function MMSE | Standardized cognitive tests | One year |
| Cognitive function CDR | Standardized cognitive tests, | One year |
| Cognitive function Montreal Cognitive Assessment | Standardized cognitive tests | One year |
| Cognitive function biochemical markers | blood sampling with NFL, NSE, s-100B, fosfor-tau and APOE | One year |
| Physical function | Standardized aggregate test of physical function, including seat raise test and grip strength measurement with validated instruments | One year |
| Coagulation Status | Blood sampling Fibrinogen, D-Dimer, Antithrombin III and platelets, Aggregate variable to determine overall coagulation status | One year |
| Covid 19 antibodies | Antibodies IgG against Covid 19 lab test | One year |
| one year |
| New need for nursing assistance at home? | Are the subjects in need of in home nursing care | one year |
| Frailty | assessed accordingly to Clinical frailty scale | One year |
| Mental fatigue | self-assessment questionnaire Mental fatigue scale | One Year |
| 28619367 | Background | Li XC, Zhang J, Zhuo JL. The vasoprotective axes of the renin-angiotensin system: Physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases. Pharmacol Res. 2017 Nov;125(Pt A):21-38. doi: 10.1016/j.phrs.2017.06.005. Epub 2017 Jun 12. |
| 32273593 | Background | Ronco C, Reis T. Kidney involvement in COVID-19 and rationale for extracorporeal therapies. Nat Rev Nephrol. 2020 Jun;16(6):308-310. doi: 10.1038/s41581-020-0284-7. |
| 32171076 | Background | Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020 Mar 28;395(10229):1054-1062. doi: 10.1016/S0140-6736(20)30566-3. Epub 2020 Mar 11. |
| 32265220 | Background | Wynants L, Van Calster B, Collins GS, Riley RD, Heinze G, Schuit E, Bonten MMJ, Dahly DL, Damen JAA, Debray TPA, de Jong VMT, De Vos M, Dhiman P, Haller MC, Harhay MO, Henckaerts L, Heus P, Kammer M, Kreuzberger N, Lohmann A, Luijken K, Ma J, Martin GP, McLernon DJ, Andaur Navarro CL, Reitsma JB, Sergeant JC, Shi C, Skoetz N, Smits LJM, Snell KIE, Sperrin M, Spijker R, Steyerberg EW, Takada T, Tzoulaki I, van Kuijk SMJ, van Bussel B, van der Horst ICC, van Royen FS, Verbakel JY, Wallisch C, Wilkinson J, Wolff R, Hooft L, Moons KGM, van Smeden M. Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal. BMJ. 2020 Apr 7;369:m1328. doi: 10.1136/bmj.m1328. |
| 32282949 | Background | Terpos E, Ntanasis-Stathopoulos I, Elalamy I, Kastritis E, Sergentanis TN, Politou M, Psaltopoulou T, Gerotziafas G, Dimopoulos MA. Hematological findings and complications of COVID-19. Am J Hematol. 2020 Jul;95(7):834-847. doi: 10.1002/ajh.25829. Epub 2020 May 23. |
| 25015102 | Background | Orde SR, Pulido JN, Masaki M, Gillespie S, Spoon JN, Kane GC, Oh JK. Outcome prediction in sepsis: speckle tracking echocardiography based assessment of myocardial function. Crit Care. 2014 Jul 11;18(4):R149. doi: 10.1186/cc13987. |
| 26134971 | Background | Dalla K, Hallman C, Bech-Hanssen O, Haney M, Ricksten SE. Strain echocardiography identifies impaired longitudinal systolic function in patients with septic shock and preserved ejection fraction. Cardiovasc Ultrasound. 2015 Jul 2;13:30. doi: 10.1186/s12947-015-0025-4. |
| 31361336 | Background | Dalla K, Bech-Hanssen O, Ricksten SE. Impact of norepinephrine on right ventricular afterload and function in septic shock-a strain echocardiography study. Acta Anaesthesiol Scand. 2019 Nov;63(10):1337-1345. doi: 10.1111/aas.13454. Epub 2019 Aug 19. |
| 32341111 | Background | Rello J, Storti E, Belliato M, Serrano R. Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers. Eur Respir J. 2020 May 21;55(5):2001028. doi: 10.1183/13993003.01028-2020. Print 2020 May. |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |