Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Uppsala University Hospital | OTHER |
Not provided
Not provided
Not provided
Not provided
The study will follow COVID-19 patients who required intensive care after 3-6 months and one year after discharge from the ICU with functional level as well as organ function to assess recovery after COVID-19. Blood and urine will be collected for biobanking.
The study will follow COVID-19 patients who required intensive care at Uppsala University Hospital and were included in the Uppsala COVID-19 biobank. The patients will be contacted after three to six months for a first follow-up with assessment of functional level in activities of daily life, psychiatric symptoms, neurological symptoms and working capacity as well as specific organ functions. The organ functions will include circulation, respiration, coagulation, immune function and kidney function. In addition, blood and urine will be collected for biobanking.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COVID-19 | Patients with PCR-confirmed COVID-19 who were treated in the intensive care unit. |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | Death | Within 90 days after admission to ICU. |
| Mortality | Death | Within 1 year after admission to ICU. |
| Renal recovery | Return of renal function measured as CKD stage. | At follow-up three to six months after ICU discharge. |
| Renal recovery | Return of renal function measured as CKD stage. | At follow-up one year after ICU discharge. |
| Respiratory recovery | Respiratory function as assessed by a clinician | Three to six months from discharge from ICU |
| Working capacity | 6 min walk test | Three to six months from discharge from ICU |
| Quality of life score | Quality of Life assessed using the 36-item short form survey by RAND. | Three to six months from discharge from ICU |
| Cognitive recovery | Cognitive screening using the Montreal Cognitive Assessment. | Three to six months from discharge from ICU |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Adult patients admitted to ICU for COVID-19.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Michael Hultström, MD. PhD. | Contact | +46186110000 | michael.hultstrom@mcb.uu.se | |
| Robert Frithiof, MD. PhD. | Contact | +46186110000 | robert.frithiof@surgsci.uu.se |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Uppsala University Hospital | Recruiting | Uppsala | 75185 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33901787 | Result | E E, R F, Oi E, Im L, M L, S R, E W, C J, M H, A M. Impaired diffusing capacity for carbon monoxide is common in critically ill Covid-19 patients at four months post-discharge. Respir Med. 2021 Jun;182:106394. doi: 10.1016/j.rmed.2021.106394. Epub 2021 Apr 15. | |
| 33494766 | Result | Hultstrom M, Lipcsey M, Wallin E, Larsson IM, Larsson A, Frithiof R. Severe acute kidney injury associated with progression of chronic kidney disease after critical COVID-19. Crit Care. 2021 Jan 25;25(1):37. doi: 10.1186/s13054-021-03461-4. No abstract available. |
Not provided
Not provided
Data will be shared on reasonable request.
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| D012769 | Shock |
| D020141 | Hemostatic Disorders |
| D058186 | Acute Kidney Injury |
| D012131 | Respiratory Insufficiency |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
Not provided
Not provided
Not provided
Not provided
Not provided
Urine, Whole blood, Dried blood, Serum, EDTA-plasma, Citrate-plasma, cheek swab.
| Frailty |
Screening for frailty using the Clinical Frailty Scale-9. |
| Three to six months from discharge from ICU |
| Activities of Daily Life | Screening of functional level for Activities of Daily Life using the 5-level EQ-5D. | Three to six months from discharge from ICU |
| Anxiety | Screening for anxiety using the Generalised Anxiety Disorder 7-item scale. | Three to six months from discharge from ICU |
| Depression | Screening for depression using the Patient Health Questionnaire 9. | Three to six months from discharge from ICU |
| Neurological recovery | Neurological function as assessed by a clinician | Three to six months from discharge from ICU |
| 39050483 | Derived | Bjarnadottir KJ, Perchiazzi G, Sidenbladh CL, Larina A, Wallin E, Larsson IM, Franzen S, Larsson AO, Sousa MLA, Segelsjo M, Hansen T, Frithiof R, Hultstrom M, Lipcsey M, Pellegrini M. Body mass index is associated with pulmonary gas and blood distribution mismatch in COVID-19 acute respiratory failure. A physiological study. Front Physiol. 2024 Jul 10;15:1399407. doi: 10.3389/fphys.2024.1399407. eCollection 2024. |
| 37865685 | Derived | Halvorsen P, Hultstrom M, Hastbacka J, Larsson IM, Eklund R, Arnberg FK, Hokkanen L, Frithiof R, Wallin E, Orwelius L, Lipcsey M. Health-related quality of life after surviving intensive care for COVID-19: a prospective multicenter cohort study. Sci Rep. 2023 Oct 21;13(1):18035. doi: 10.1038/s41598-023-45346-2. |
| 37573366 | Derived | Bark L, Larsson IM, Wallin E, Simren J, Zetterberg H, Lipcsey M, Frithiof R, Rostami E, Hultstrom M. Central nervous system biomarkers GFAp and NfL associate with post-acute cognitive impairment and fatigue following critical COVID-19. Sci Rep. 2023 Aug 12;13(1):13144. doi: 10.1038/s41598-023-39698-y. |
| 36271419 | Derived | Hultstrom M, Lipcsey M, Morrison DR, Nakanishi T, Butler-Laporte G, Chen Y, Yoshiji S, Forgetta V, Farjoun Y, Wallin E, Larsson IM, Larsson A, Marton A, Titze JM, Nihlen S, Richards JB, Frithiof R. Dehydration is associated with production of organic osmolytes and predicts physical long-term symptoms after COVID-19: a multicenter cohort study. Crit Care. 2022 Oct 21;26(1):322. doi: 10.1186/s13054-022-04203-w. |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006474 | Hemorrhagic Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D012120 | Respiration Disorders |