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The goal of this study is to establish a prospective observational cohort of individuals with functional GI disorders (functional constipation, irritable bowel syndrome, chronic nausea, functional diarrhea, and functional dyspepsia, as well as a subset of these individuals starting neuromodulation for their functional GI disorder) and collect clinical information and specimens. This information will be used in order to establish a patient registry with detailed clinical data and a specimen repository for future research as well as to specifically identify environmental, genetic, physiological, and psycho-social factors associated with functional GI disorders.
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| Measure | Description | Time Frame |
|---|---|---|
| Single Nucleotide Polymorphism (SNP) genotyping | In this study, we anticipate identifying differential functional genomic profiles (metagenomes) and metabolites (metabolomes) between patients with different functional GI disorders, with detailed species-specific reconstruction of microbial metabolic pathways, their complement of gene orthologs, taxonomic distributions, and abundance profiles. | Baseline visit |
| Whole genome analysis | In this study, we anticipate identifying differential functional genomic profiles (metagenomes) and metabolites (metabolomes) between patients with different functional GI disorders, with detailed species-specific reconstruction of microbial metabolic pathways, their complement of gene orthologs, taxonomic distributions, and abundance profiles. | Baseline visit |
| Proteomics | In this study, we anticipate identifying differential functional genomic profiles (metagenomes) and metabolites (metabolomes) between patients with different functional GI disorders, with detailed species-specific reconstruction of microbial metabolic pathways, their complement of gene orthologs, taxonomic distributions, and abundance profiles. | Baseline visit |
| Microbiome analysis | In this study, we anticipate identifying differential functional genomic profiles (metagenomes) and metabolites (metabolomes) between patients with different functional GI disorders, with detailed species-specific reconstruction of microbial metabolic pathways, their complement of gene orthologs, taxonomic distributions, and abundance profiles. | Baseline visit |
| Microbiome analysis | In this study, we anticipate identifying differential functional genomic profiles (metagenomes) and metabolites (metabolomes) between patients with different functional GI disorders, with detailed species-specific reconstruction of microbial metabolic pathways, their complement of gene orthologs, taxonomic distributions, and abundance profiles. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients 18 years or older with a functional GI disorder
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| Name | Affiliation | Role |
|---|---|---|
| Kyle Staller, MD MPH | Massachusetts General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States |
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| ID | Term |
|---|---|
| D005767 | Gastrointestinal Diseases |
| ID | Term |
|---|---|
| D004066 | Digestive System Diseases |
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| 3 months after enrollment |
| Microbiome analysis | In this study, we anticipate identifying differential functional genomic profiles (metagenomes) and metabolites (metabolomes) between patients with different functional GI disorders, with detailed species-specific reconstruction of microbial metabolic pathways, their complement of gene orthologs, taxonomic distributions, and abundance profiles. | 6 months after enrollment |
| Microbiome analysis | In this study, we anticipate identifying differential functional genomic profiles (metagenomes) and metabolites (metabolomes) between patients with different functional GI disorders, with detailed species-specific reconstruction of microbial metabolic pathways, their complement of gene orthologs, taxonomic distributions, and abundance profiles. | 1 year after enrollment |
| Diet and Lifestyle Questionnaire | This questionnaire evaluates patients' diet, lifestyle, and symptoms relating to their functional GI disorder. | Baseline visit |
| Diet and Lifestyle Questionnaire | This questionnaire evaluates patients' diet, lifestyle, and symptoms relating to their functional GI disorder. | 3 months after enrollment |
| Diet and Lifestyle Questionnaire | This questionnaire evaluates patients' diet, lifestyle, and symptoms relating to their functional GI disorder. | 6 months after enrollment |
| Diet and Lifestyle Questionnaire | This questionnaire evaluates patients' diet, lifestyle, and symptoms relating to their functional GI disorder. | 1 year after enrollment |