Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Lack of enrollment.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This is a longitudinal observational study on patients with gastrointestinal and related disease. The study will be conducted for at least 10 years, following each participant over time, as they either go through relapses and remissions, or progression of their disease.
This is a longitudinal, observational study whose main goal is to identify the human and microbial determinants of gastrointestinal diseases. Molecular and metadata will be collected from a large study population at multiple time points. Machine learning will be applied to all data, and models will be evaluated for development of novel diagnostic and therapeutic tools.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ulcerative Colitis | Participants with ulcerative colitis. | ||
| Crohn's Disease | Participants with Crohn's disease. | ||
| Obesity | Participants that are obese. | ||
| Colon Polyps | Participants with colon polyps. | ||
| Eosinophilic esophagitis | Participants with Eosinophilic esophagitis | ||
| Gastroesophageal Reflux Disease (GERD) | Participants with Gastroesophageal Reflux Disease (GERD). | ||
| Gastritis | Participants with gastritis. | ||
| Gastric ulcers | Participants with gastric ulcers. |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Identification of human determinants of gastrointestinal diseases. | Identification of biomarkers that indicate gastrointestinal diseases. | Up to 10 years |
| Identification of microbial determinants of gastrointestinal diseases. | Identification of microbial species that indicate gastrointestinal disease. | Up to 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| Prediction of efficacy of biologics in treating IBD. | Prediction of the efficacy of a biologic medication against IBD based on molecular data and metadata. | Up to 10 years. |
| Development of a molecular test for C. difficile infection (CDI) |
Not provided
Inclusion criteria
Exclusion Criteria:
Not provided
Not provided
Not provided
Patients 18 years old or older who visit WAGI for the following reasons:
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Momchilo Vuyisich | Viome | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Viome Life Sciences | Bothell | Washington | 98011 | United States |
Not provided
Not provided
Not provided
Not provided
| Duodenal ulcers | Participants with duodenal ulcers. |
| Intestinal metaplasia | Participants with intestinal metaplasia (risk factor for esophageal cancer). |
| Gastric Cancer | Participants with gastric cancer. |
| Lymphocytic/Microscopic Colitis | Participants with Lymphocytic/Microscopic Colitis. |
| Celiac Sprue | Participants with Celiac Sprue. |
| Irritable Bowel Syndrome (IBS) | Participants with IBS. |
| Small intestinal bacterial overgrowth (SIBO) | Participants with SIBO. |
| Non-alcoholic Fatty Liver Disease (NAFLD) | Participants with NAFLD. |
| Gallstone disease | Participants with Gallstone disease. |
Development of a molecular test for C. difficile infection (CDI)
| Up to 10 years. |
| Quantify change in microbial species over time post colonoscopy | Quantification of changes observed in the microbiome post colonoscopy. | Up to 10 years. |
| ID | Term |
|---|---|
| D003093 | Colitis, Ulcerative |
| D003424 | Crohn Disease |
| D009765 | Obesity |
| D003111 | Colonic Polyps |
| D057765 | Eosinophilic Esophagitis |
| D005764 | Gastroesophageal Reflux |
| D001471 | Barrett Esophagus |
| D004938 | Esophageal Neoplasms |
| D005756 | Gastritis |
| D013276 | Stomach Ulcer |
| D004381 | Duodenal Ulcer |
| D013274 | Stomach Neoplasms |
| D046730 | Colitis, Lymphocytic |
| D046728 | Colitis, Microscopic |
| D002446 | Celiac Disease |
| D043183 | Irritable Bowel Syndrome |
| D065626 | Non-alcoholic Fatty Liver Disease |
| D002769 | Cholelithiasis |
| D005767 | Gastrointestinal Diseases |
| ID | Term |
|---|---|
| D003092 | Colitis |
| D005759 | Gastroenteritis |
| D004066 | Digestive System Diseases |
| D015212 | Inflammatory Bowel Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007417 | Intestinal Polyps |
| D011127 | Polyps |
| D020763 | Pathological Conditions, Anatomical |
| D004941 | Esophagitis |
| D004935 | Esophageal Diseases |
| D004802 | Eosinophilia |
| D007960 | Leukocyte Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D015154 | Esophageal Motility Disorders |
| D003680 | Deglutition Disorders |
| D011230 | Precancerous Conditions |
| D009369 | Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D006258 | Head and Neck Neoplasms |
| D013272 | Stomach Diseases |
| D010437 | Peptic Ulcer |
| D004378 | Duodenal Diseases |
| D008286 | Malabsorption Syndromes |
| D008659 | Metabolic Diseases |
| D003109 | Colonic Diseases, Functional |
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D001660 | Biliary Tract Diseases |
Not provided
Not provided