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Aim of this trial is to define if Concentration at the effector site (Ce) of Ketamine, calculated with DOMINO model infusion pump are correlated with Bispectral Index BIS values during general anaesthesia for breast surgery.
Correlation between Concentration at the effector site (Ce) of Ketamine and Bispectral Index (BIS) values during general anaesthesia for breast surgery has not been defined yet.
We want to analyze this correlation during general anaesthesia conducted using Propofol, ketamine and remifentanil. All of these drugs will be delivered with Targeted-ControlledInfusion pumps (in particular Eleveld for Propofol, Minto for Remifentanil and Domino for Ketamine).
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bispectral Index | Device | Comparing Bispectral index values (usually adopted during general anaesthesia monitoring) to Ketamine concenetration at the effector site calculated with Domino model pump (usually adopted for Ketamine infusion during general anaesthesia) |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between Concentration at the effector site of Ketamine and BIS values | Discover if there is linear correlation between Concentration at the effector site of Ketamine and BIS values during standard general anaesthesia conducted with Propofol, remifenatnil and ketamine delivered with targeted controlled infusion pumps, usually adopted in our Hospital to delivery general anaesthesia | We will collected data about Drugs concentration and BIS values during general anaesthesia. We will collect BIS and TCI Ketamine values during all the duration of anesthesia, form the start of ketamine bolus until the emergence from anesthesia |
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Inclusion Criteria:
Exclusion Criteria:
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Women undergoing brast cancer surgery
Adult Women undergoing breast surgery for breast cancer
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ULSS 2 Marca Trevigiana | Treviso | Tv | 31100 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39485729 | Derived | Linassi F, Troyas C, Kreuzer M, Spano L, Burelli P, Schneider G, Zanatta P, Carron M. Effect of Ketamine on the Bispectral Index, Spectral Edge Frequency, and Surgical Pleth Index During Propofol-Remifentanil Anesthesia: An Observational Prospective Trial. Anesth Analg. 2025 Jun 1;140(6):1276-1285. doi: 10.1213/ANE.0000000000007255. Epub 2024 Nov 1. |
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| ID | Term |
|---|---|
| D056805 | Consciousness Monitors |
| ID | Term |
|---|---|
| D013523 | Surgical Equipment |
| D004864 | Equipment and Supplies |
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