Intraperitoneal Instillation of Levobupivacaine With Morphine Versus Levobupivacaine With Magnesium Sulfate for Postoperative Analgesia

Comparison of Intra-Peritoneal Instillation of Levobupivacaine With Morphine Hydrochloride Versus Levobupivacaine With Magnesium Sulfate for Post-Operative Pain Relief After Laparoscopic Cholecystectomy

This is a prospective randomized study that included 60 patients and was divided into two equal groups of patients who were scheduled for LC, Ages 18 and 60 years, both sexes, ASA I-II and BMI 19 - 39. Group A received 30 ml levobupivacaine (0.25%) plus 3 mg morphine intraperitoneal at the site of surgery in the bed of the gallbladder via the navel port with the patient in a Trendelenburg position, Group B received 30 ml levobupivacaine (0.25%) plus 50 mg/kg magnesium sulfate in the same pattern as in the A group.

Inclusion Criteria:

• Patients who were scheduled for L.C,
• Ages 18 and 60 years
• ASA I-II and
• BMI 19 - 39

Exclusion Criteria:

• Patients with hepatic or renal dysfunction
• use of opioids 24 hrs prior to the study
• treatment with steroids prior to surgery
• drug or alcohol abuse, allergy to any of the study drugs
• chronic pain syndrome as a result of neurological disease