Translational and Clinical Aspects of Metabolic, Anabolic and Endothelial Dysfunction in Heart Failure

Translational and Clinical Aspects of Metabolic, Anabolic and Endothelial Dysfunction in Herat Failure

In patients with HF cardiac output, metabolism and endothelial function will be studied during and after treatment with ghrelin infusion

In patients with HF cardiac output, metabolism and endothelial function will be studied during and after treatment with ghrelin infusion (single dose).

The following parameters will be collected: routine clinical parameters, endothelial function, cardiac structure and function by echocardiography, non-invasively assessed cardiac output and hemodynamics, serologic and of cardiac and renal function, sympathetic and RAS activation, metabolism, anabolic hormone function, inflammation, fibrosis, oxidative stress and apoptosis.

15 patients each group in are adequate to detect a difference between groups and before vs after ghrelin administration in metabolism, anabolic function and endothelial function with a power of 90% and two-sided significance of 5%.

Inclusion Criteria:

1. Current or past signs of clinical HF according to the Framingham criteria
2. LVEF<40%
3. NT-proBNP > 300 ng/L

Exclusion Criteria:

1. Inability to or unwillingness to provide informed consent,
2. Participation in research study that involves research drug administration or contraindication to any of the clinically indicated procedures.