Keto Drinks as a Meal Primer in Patients With Type 2 Diabetes

3-hydroxybutyrate as a Meal Primer in Patients With Type 2 Diabetes

The main objective of this clinical trial is to study the effects of orally administered ketone drinks containing the ketone body, 3-hydroxybutyrate (3-OHB), just before a meal in patients with type 2 diabetes. Moreover the investigators will compare the effects of two different ketone drinks.

The hypothesis is:

3-OHB as a pre-meal may:

• Lower postprandial blood glucose and lipids.
• Mediate release of intestinal hormones and affect gastric emptying.
• Affect appetite and other subjective measures related to food intake.

The effects of 3-OHB as a pre-meal will be investigated by blood samples, isotopic tracers examinations, paracetamol test, questionnaires and meal test.

Inclusion Criteria:

• Type 2 diabetes diagnosis, metformin treated or dietary treated
• HbA1C < 80 mmol/mol
• 25 < BMI < 35
• Written consent

Exclusion Criteria:

• Severe comorbidity
• Treatment with insulin, GLP-1 analogues, SGLT-2-inhibitors or sulfonylureas
• Specific diets, e.g. ketogenic diet
• PI finds the patient not fit (e.g. mental illness, too nervous, unacceptable screening blood tests or other)