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Immunonutrition (IN) appears to reduce infective complications and in-hospital length of stay (LOS) after gastrointestinal surgery. More specifically, it seems to be beneficial also in gastric cancer surgery. Potential benefits of combining preoperative IN (PIN) with protocols of enhanced recovery after surgery (ERAS) in reducing LOS in laparoscopic total gastrectomy are yet to be determined.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients receiving immunonutrition supply | Dietary Supplement: Immunonutrition nutridrinks 3 times a day 5 days prior surgery plus maltodextrins the day of surgery |
| |
| historical control group | standard dietary advice |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| immunonutrition | Dietary Supplement | nutridrinks 3 times a day 5 days prior surgery plus maltodextrins the day of surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| 30-days postoperative complications | Rate of any complication after colorectal resection | up to 30 days after discharge |
| LOS | number of days between primary colorectal resection and discharge | up to 30 days after discharge |
| Measure | Description | Time Frame |
|---|---|---|
| Anastomotic leak | rate of any postoperative leakage of oesophagojejunal, jejunojejunal anastomosis, clinically, radiologically or endoscopically demonstrated | up to 30 days after discharge |
| Pneumonia |
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Inclusion Criteria:
Exclusion Criteria:
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All normonourished patients undergoing elective ERAS laparoscopic total gastrectomy for cancer at Minimally Invasive Surgery Unit of Tor Vergata University Hospital
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35816241 | Derived | Franceschilli M, Siragusa L, Usai V, Dhimolea S, Pirozzi B, Sibio S, Di Carlo S. Immunonutrition reduces complications rate and length of stay after laparoscopic total gastrectomy: a single unit retrospective study. Discov Oncol. 2022 Jul 11;13(1):62. doi: 10.1007/s12672-022-00490-5. |
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data available on request
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| ID | Term |
|---|---|
| D013274 | Stomach Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| ID | Term |
|---|---|
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
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| ID | Term |
|---|---|
| D000093702 | Immunonutrition Diet |
| ID | Term |
|---|---|
| D004032 | Diet |
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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rate of radiologically demonstrated pneumonia
| up to 30 days after discharge |
| Ileus | rate of any ileus clinically demonstrated | up to 30 days after discharge |
| Prolonged length of stay | rate of any patient discharged after 15 days | up to 30 days after discharge |
| Readmission | Rate of any unplanned readmission after discharge | up to 30 days after discharge |
| Mortality | Rate of any mortality | up to 30 days after discharge |
| Time of first defacation | time to first bowel opened to stool | up to 30 days after discharge |
| Time of tolerated fluid intake | time to first tolerated fluid intake | up to 30 days after discharge |
| Time of tolerated food intake | time to first tolerated food intake | up to 30 days after discharge |
| D005767 |
| Gastrointestinal Diseases |
| D013272 | Stomach Diseases |