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Immunonutrition (IN) appears to reduce infective complications and in-hospital length of stay (LOS) after gastrointestinal surgery. More specifically, it seems to be beneficial also in colorectal cancer surgery. Potential benefits of combining preoperative IN (PIN) with protocols of enhanced recovery after surgery (ERAS) in reducing LOS in laparoscopic surgery are yet to be determined.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A | patients receiving immunonutrition supply |
| |
| B | patients receiving standard dietary advice |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Immunonutrition | Dietary Supplement | nutridrinks 3 times a day 5 days prior surgery plus maltodextrins the day of surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Length of hospital stay | number of days between primary colorectal resection and discharge | up to 30 days after discharge |
| Measure | Description | Time Frame |
|---|---|---|
| Time to postoperative food intake | number of days between primary colorectal resection and refeeding | up to 30 days after discharge |
| Time to first defecation | number of days between primary colorectal resection and first defecation |
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Inclusion Criteria:
Exclusion Criteria:
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All normonourished patients undergoing elective ERAS laparoscopic colorectal resections for cancer at Minimally Invasive Surgery Unit of Tor Vergata University Hospital
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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| ID | Term |
|---|---|
| D000093702 | Immunonutrition Diet |
| ID | Term |
|---|---|
| D004032 | Diet |
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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| up to 30 days after discharge |
| 30-days postoperative complications | Rate of any complication after colorectal resection | up to 30 days after discharge |
| Surgical site infection | rate of any surgical site infection clinically demonstrated | up to 30 days after discharge |
| Anastomotic leak | rate of any postoperative leakage of colo-rectal, colo-colic or ileo-colic anastomosis, clinically, radiologically or endoscopically demonstrated | up to 30 days after discharge |
| Readmission | Rate of any unplanned readmission after discharge | up to 90 days after discharge |
| 30-days Mortality | Rate of any mortality | up to 30 days after discharge |
| Pneumonia | rate of radiologically demonstrated pneumonia | up to 30 days after discharge |
| Ileus | rate of any ileus clinically demonstrated | up to 30 days after discharge |
| Prolonged length of stay | rate of any patient discharged after 8 days | up to 30 days after discharge |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |