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Evaluation of Infective Risk, Efficacy of Bacterial Prophylaxis and Validation of sepsis scores NEWS (National Early Warning Score) and qSOFA (Quick Sequential Organ Failure Assessment) in Patient With Acute Myeloid Leukemia Treated With Intensive Chemotherapy
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| Measure | Description | Time Frame |
|---|---|---|
| Mortality risk | Ability of NEWS and qSOFA score to predict mortality risk calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve) | At baseline (fever onset), change at 24 hours from baseline, change at 48 hours from baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Systemic Inflammatory Response Syndrome (SIRS) development | Ability of NEWS and qSOFA score to predict SIRS development calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve) | At baseline (fever onset), change at 24 hours from baseline, change at 48 hours from baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients affected by Acute Myeloid Leukemia that had received between JAN2001 and DEC2019 an intensive chemotherapy cycle either as induction or consolidation regimen
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chiara Frairia, MD | Contact | +390116335612 | cfrairia@cittadellasalute.to.it |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AOU Città della Salute e della Scienza di Torino | Recruiting | Torino | 10126 | Italy |
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| Amine requirement |
Ability of NEWS and qSOFA score to predict vasoactive drugs requirement calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve) |
| At baseline (fever onset), change at 24 hours from baseline, change at 48 hours from baseline |
| Respiratory failure | Ability of NEWS and qSOFA score to predict respiratory failure calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve) | At baseline (fever onset), change at 24 hours from baseline, change at 48 hours from baseline |
| Ventilation support | Ability of NEWS and qSOFA score to predict ventilation support necessity calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve) | At baseline (fever onset), change at 24 hours from baseline, change at 48 hours from baseline |
| Intensive care unit (ICU) admission | Ability of NEWS and qSOFA score to predict ICU admission calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve) | At baseline (fever onset), change at 24 hours from baseline, change at 48 hours from baseline |
| Bloodstream infections | Ability of NEWS and qSOFA score to predict severity of bloodstream infection calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve) | From date of fever onset until the date of fever resolution, assessed up to 60 days |
| Number of infections | Cumulative incidence of infections in patients with levofloxacin prophylaxis vs. patients without levofloxacin prophylaxis | From date of neutrophils count <500/mmc until the day of neutrophils count >=500/mmc, assessed up to 60 days |
| ID | Term |
|---|---|
| D015470 | Leukemia, Myeloid, Acute |
| D064146 | Chemotherapy-Induced Febrile Neutropenia |
| ID | Term |
|---|---|
| D007951 | Leukemia, Myeloid |
| D007938 | Leukemia |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D064147 | Febrile Neutropenia |
| D009503 | Neutropenia |
| D000380 | Agranulocytosis |
| D007970 | Leukopenia |
| D000095542 | Cytopenia |
| D007960 | Leukocyte Disorders |
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