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The Life University Center for Chiropractic Research is conducting a research study to better understand the physiologic and brain-based differences between the touch and force components of the chiropractic adjustment. Eligible individuals will either receive a chiropractic adjustment with force or a non-force stimulation. Individuals in the force stimulation group will receive an active spinal adjustment with a handheld instrument called an Activator. Individuals in the non-force stimulation group will have one Activator placed on the spine and another Activator clicked away from the spine. This study is not randomized. The first participant will receive an active spinal adjustment, and the second participant will receive a non-force stimulation at the same locations as the first participant. This pattern repeats until all individuals have been recruited (n=30). Outcome assessments include resting state electroencephalography (EEG), electrocardiography (ECG), and blood pressure. Outcome assessments will be captured prior to the adjustment or non-force stimulation, after the adjustment or non-force stimulation, and one week later. Individuals will also undergo a standard health history and chiropractic physical exam at the start of participation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Force | Experimental | Chiropractic spinal adjustment with force |
|
| Touch | Active Comparator | non-force stimulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Chiropractic spinal adjustment | Other | Chiropractic spinal adjustment |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Electroencephalography (EEG) Power spectrum | 64 channels of EEG will be recorded. A fast Fourier transform will be computed to provide a power spectrum of frequencies 1-50. | Baseline, beginning of the study |
| Electroencephalography (EEG) Power spectrum | 64 channels of EEG will be recorded. A fast Fourier transform will be computed to provide a power spectrum of frequencies 1-50. | through study completion, an average of 1 year |
| Electroencephalography (EEG) Power spectrum | 64 channels of EEG will be recorded. A fast Fourier transform will be computed to provide a power spectrum of frequencies 1-50. | One week follow up |
| Electrocardiogram (ECG) R-R intervals | Three leads will be placed on the torso to capture a Lead II ECG. R-R intervals will be calculated. | Baseline, beginning of the study |
| Electrocardiogram (ECG) R-R intervals | Three leads will be placed on the torso to capture a Lead II ECG. R-R intervals will be calculated. | through study completion, an average of 1 year |
| Electrocardiogram (ECG) R-R intervals | Three leads will be placed on the torso to capture a Lead II ECG. R-R intervals will be calculated. | one-week follow up |
| Blood pressure | Blood pressure will be captured using an automatic blood pressure cuff |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stephanie Sullivan, PhD, DC | Life Univeristy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Life University Center for Chiropractic Research | Atlanta | Georgia | 30308 | United States |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Apr 24, 2026 | |
| Reset | May 18, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Apr 24, 2026 | May 18, 2026 |
| ID | Term |
|---|---|
| D026882 | Manipulation, Chiropractic |
| ID | Term |
|---|---|
| D026201 | Musculoskeletal Manipulations |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
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Participants will be masked to whether they are receiving an adjustment with force or a non-force stimulation
| Non-force simulation |
| Other |
Non-force simulation |
|
| Baseline, beginning of the study |
| Blood pressure | Blood pressure will be captured using an automatic blood pressure cuff | through study completion, an average of 1 year |
| Blood pressure | Blood pressure will be captured using an automatic blood pressure cuff | one-week follow up |