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The Life University Center for Chiropractic Research is conducting a study to better understand the relationship between subjective stress measures and brain patterns during resting state and an auditory oddball task. A secondary aim is to evaluate the impact of a single session of chiropractic care on the resting state and P300 time locked response after a one-week wait period. An additional outcome assessment for this study will be the recording of an electrocardiogram (ECG) of each participant that will be used to analyze their heart rate variability (HRV). Eligible individuals will receive a physical exam to ensure safety during all procedures. They will then sit for a 6-minute resting state EEG and an auditory oddball task. They will complete a series of questionnaires assessing stress. They will receive a chiropractic adjustment using a handheld instrument called an Activator. They will return one week later for a follow-up assessment consisting of the 6-minute resting state EEG, auditory oddball task, and the questionnaires assessing stress.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stress | Experimental | Individuals under various degrees of stress |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Chiropractic adjustment using an activator | Other | Chiropractic adjustment using an activator |
|
| Measure | Description | Time Frame |
|---|---|---|
| Electroencephalography Power spectrum | 6 minutes of resting state EEG with eyes closed. 64 channels of EEG will be recorded. A fast Fourier transform will be computed to provide a power spectrum of frequencies 1-50. | Baseline (Pre) |
| Electroencephalography Power spectrum | 6 minutes of resting state EEG with eyes closed. 64 channels of EEG will be recorded. A fast Fourier transform will be computed to provide a power spectrum of frequencies 1-50. | one-week (post) |
| Auditory oddball task | Auditory oddball task with 200 common and 40 rare stimuli. P300 evoked related potential evaluated through capturing EEG. | Baseline (Pre) |
| Auditory oddball task | Auditory oddball task with 200 common and 40 rare stimuli. P300 evoked related potential evaluated through capturing EEG. | one-week (post) |
| Heart rate variability (HRV) | ECG recording will be used to evaluate HRV from R-R intervals. | Baseline (Pre) |
| Heart rate variability (HRV) | ECG recording will be used to evaluate HRV from R-R intervals. | one-week (post) |
| Weekly Stress Inventory Short Form | 25 questions. Likert scale: did not happen; happended but not successful; slightly stressful; mildly stressful; moderately stressful; stressful; very stressful; extremely stressful. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stephanie Sullivan, DC, PhD | Life University Center for Chiropractic Research | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Life University Center for Chiropractic Research | Atlanta | Georgia | 30308 | United States |
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| Baseline (Pre) |
| Weekly Stress Inventory Short Form | 25 questions. Likert scale: did not happen; happended but not successful; slightly stressful; mildly stressful; moderately stressful; stressful; very stressful; extremely stressful. | one-week (post) |
| Hamilton Anxiety Rating Scale | 14 questions. Likert scale: not true at all; rarely true; sometimes true; often true; true nearly all the time. | Baseline (pre) |
| Hamilton Anxiety Rating Scale | 14 questions. Likert scale: not true at all; rarely true; sometimes true; often true; true nearly all the time. | one-week (post) |
| Connor Davidson Resilience Scale - 25 | 25 questions. Likert scale: not true at all; rarely true; sometimes true; often true; true nearly all the time. | baseline (pre) |
| Connor Davidson Resilience Scale - 25 | 25 questions. Likert scale: not true at all; rarely true; sometimes true; often true; true nearly all the time. | one-week (post) |
| Severity of Acute Stress Symptoms | 7 questions. Likert scale: never; almost never; sometimes; fairly often; very often. | baseline (pre) |
| Severity of Acute Stress Symptoms | 7 questions. Likert scale: never; almost never; sometimes; fairly often; very often. | one-week (post) |
| Brief Resilience Scale | 6 questions. Likert scale: strongly disagree; disagree; neutral; agree; strongly agree | baseline (pre) |
| Brief Resilience Scale | 6 questions. Likert scale: strongly disagree; disagree; neutral; agree; strongly agree | one-week (post) |
| Daily Stress Scale | 6 questions. Numeric rating scale from 0-10. O indicating no stress and 10 indicating extremly stressful. | baseline (pre) |
| Daily Stress Scale | 6 questions. Numeric rating scale from 0-10. O indicating no stress and 10 indicating extremly stressful. | one-week (post) |