The objectives of this trial are to assess the safety, tolerability and efficacy of A197 ophthalmic solution in comparison to a vehicle control in the treatment of subjects with Dry Eye Disease.

Inclusion Criteria:

• Written informed consent must be obtained prior to any study-related assessments
• Have a history of Dry Eye Disease in both eyes for at least 12 months prior to Visit 1
• Willing and able to follow instructions and can be present for required study visits

Exclusion Criteria:

• Women who are pregnant or breastfeeding
• Use of topical ophthalmic medications, artificial tears, eye drops and gels in either eye
• Use of contact lenses within 90 days prior to Visit 1 and throughout the study
• Have had an ocular infection in either eye within 90 days prior to Visit 1