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The aim of this study is to evaluate the effects of the consumption of bread produced with the addition of pomegranate peels, which has a high antioxidant content, on blood glucose and lipid parameters, and some oxidant-antioxidant enzymes and lipid peroxidation in individuals with type 2 diabetes.
Between 01.02.2022 and 30.05.2022 with Specialist Dr. Emel SENOL's approval, by Specialist Dr. Akkız Zuhal ÖZTAŞ
The study will be conducted with 30 volunteers who present to the City Hospital Internal Medicine Polyclinic in Mersin.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| People with type 2 diabetes who eat bread with pomegranate crust - Experimental Group | Experimental | Individuals with type 2 diabetes who met the inclusion criteria and participated in the study will divided into two groups by Specialist Akkız Zuhal ÖZTAŞ and Specialist Doctor Emel ŞENOL, and they will be asked to consume the breads produced (in the preliminary study) produced as a standard (n=15) and with the addition of pomegranate peel (n=15) for eight weeks. The individuals participating in the study will be asked not to change their eating habits, physical activity habits, and drug treatments during the study period. Each individual participating in the study will be provided with the required amount of bread during the study and will be contacted weekly by Zeynep ÇAMLIK, a specialist dietitian, to verify whether they consume bread regularly. |
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| No intervention - Control Group | No Intervention | Individuals with type 2 diabetes will not eat pomegranate crust bread |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pomegranate Peel | Dietary Supplement | Standard bread and test breads (with added pomegranate peel) to be used in the study will be produced by Asst. Prof. Özlem ÖZPAK AKKUŞ in the Nutrition Principles Laboratory of Toros University. For standard bread, 900 ml of water, 42 fresh yeast, 12 g of salt and 12 g of sunflower oil will be added to 1000 g of sifted whole wheat flour and the prepared bread mixture will be divided into 40 equal parts. To make bread with pomegranate peel added, 1000 g of sifted whole wheat flour, 20 g of pomegranate peel powder, 914 ml of water, 42 g of fresh yeast, 12 g of salt and 12 g of sunflower oil will be added and the prepared bread mixture is divided into 40 equal parts with 500 mg of pomegranate peel powder in each piece). |
| Measure | Description | Time Frame |
|---|---|---|
| Biochemical Blood Parameters | Examination of between group differences regarding lipid profile | First day at the beginning of the study |
| Biochemical Blood Parameters | Examination of between group differences regarding HbA1c | First day at the beginning of the study |
| Biochemical Blood Parameters | Examination of between group differences regarding insulin | First day at the beginning of the study |
| Biochemical Blood Parameters | Examination of between group differences regarding TAC | First day at the beginning of the study |
| Biochemical Blood Parameters | Examination of between group differences regarding TBARS | First day at the beginning of the study |
| Anthropometric Measurements - Weight | Examination of between group differences regarding weight in kilogram | First day at the beginning of the study |
| Anthropometric Measurements - Height | Examination of between group differences regarding height in meter | First day at the beginning of the study |
| Anthropometric Measurements - Body Mass Index |
| Measure | Description | Time Frame |
|---|---|---|
| Biochemical Blood Parameters | Comparison of between group differences regarding lipid profile | Eight weeks after the start of the study |
| Biochemical Blood Parameters | Comparison of between group differences regarding HbA1c |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Özlem ÖZPAK AKKUŞ | Mersin | Yenişehir | 33100 | Turkey (Türkiye) |
Data can be shared in consultation with the principal investigator.
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data can be shared after the research is published in consultation with the principal investigator.
data can be shared after the research is published in consultation with the principal investigator.
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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The study will conduct by using a prospective randomized double-blind clinical trial model.
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Participants will not know which type of bread to eat.
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Examination of between group differences regarding body mass index (BMI = weight in kilogram / height in meter 2)
| First day at the beginning of the study |
| Anthropometric Measurements - Waist Circumference | Examination of between group differences regarding waist circumference in centimeters | First day at the beginning of the study |
| Anthropometric Measurements - Hip Circumference | Examination of between group differences regarding hip circumference in centimeters | First day at the beginning of the study |
| Eight weeks after the start of the study |
| Biochemical Blood Parameters | Comparison of between group differences regarding insulin | Eight weeks after the start of the study |
| Biochemical Blood Parameters | Comparison of between group differences regarding TAC | Eight weeks after the start of the study |
| Biochemical Blood Parameters | Comparison of between group differences regarding TBARS | Eight weeks after the start of the study |
| Anthropometric Measurements - Weight | Examination of between group differences regarding weight in kilogram | Eight weeks after the start of the study |
| Anthropometric Measurements - Height | Examination of between group differences regarding height in meter | Eight weeks after the start of the study |
| Anthropometric Measurements - Body Mass Index | Examination of between group differences regarding body mass index (BMI = weight in kilogram / height in meter 2) | Eight weeks after the start of the study |
| Anthropometric Measurements - Waist Circumference | Examination of between group differences regarding waist circumference in centimeters | Eight weeks after the start of the study |
| Anthropometric Measurements - Hip Circumference | Examination of between group differences regarding hip circumference in centimeters | Eight weeks after the start of the study |
| D004700 | Endocrine System Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |