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This study is aimed to determine the post operative pain after laparoscopic cholecystectomy by dividing patients into three different group. Group A will receive lidocaine 2mg/kg bolus at induction followed by 1.5mg/kg/hr infusion. Group B will receive bilateral subcostal TAP block with 0.375% 20ml Ropivicaine on each side. Group C will not receive any additional pain regime apart from the routine intraoperative analgesics. Pain score will be assessed post operatively for 24 hours at regular intervals using visual analog score.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lidocaine Group | Experimental | After induction of anaesthesia, a bolus of 2mg/kg intravenous lidocaine will be given followed by Lidocaine infusion at the rate of 1.5 mg/kg/hour which will be stopped at the end of surgery. |
|
| TAP group | Experimental | After completion of procedure and before extubation, bilateral ultrasound guided subcoastal transversus abdominis plane (TAP) block will be performed by the primary anaesthetist. After taking aseptic measures, with patient in supine position a high frequency (6-13 MHz) linear ultrasound probe will be placed obliquely just inferior to the costal margin over the anterior abdominal wall. With the help of a 21G or 22G, 100 mm needle, 20 ml of 0.375% Ropivacaine will be injected between rectus sheath and fascia of transversus abdominis muscle, bilaterally. |
|
| Control group | No Intervention | No additional intervention will be given to this group |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lidocaine IV | Drug | Bolus and infusion of lidocaine will be administered |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Pain score | Pain score will be assessed using visual analog scoring system (0: No pain and 10: Worst Imaginable Pain) | On arrival in PACU (0 hours) |
| Pain score | Pain score will be assessed using visual analog scoring system (0: No pain and 10: Worst Imaginable Pain) | At 2 hours |
| Pain score | Pain score will be assessed using visual analog scoring system (0: No pain and 10: Worst Imaginable Pain) | At 4 hours |
| Pain score | Pain score will be assessed using visual analog scoring system (0: No pain and 10: Worst Imaginable Pain) | At 6 hours |
| Pain score | Pain score will be assessed using visual analog scoring system (0: No pain and 10: Worst Imaginable Pain) | At 12 hours |
| Pain Score | Pain score will be assessed using visual analog scoring system (0: No pain and 10: Worst Imaginable Pain) | At 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Post operative nausea and vomiting | Nausea and vomiting score would be assess using Bellville scoring system (0: No nausea or vomiting, 1: nausea, 2: nausea and belching, 3: vomiting) | On arrival, At 2 hours, 4 hours, 6 hours, 12 hours and 24 hours |
| Patient Satisfaction |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Haris Sheikh, MBBS | Aga Khan University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aga Khan University Hospital | Karachi | Sindh | 74450 | Pakistan |
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| Ropivacaine |
| Drug |
Bilateral TAP block will be given to these patients |
|
Patient satisfaction will be assessed on Likert Scale (Completely Disagree, Disagree, Neutral, Agree, Completely Agree) |
| At 24 hours or discharge |
| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D000077212 | Ropivacaine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |
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