Intravenous Tranexamic Acid Reducing Intraoperative Blood Loss in Huge Meningiomas Resection

Effect of Tranexamic Acid on Intraoperative Blood Loss in Patients Undergoing Brain Meningioma Resections: Study Protocol of a Randomised Controlled Trial

Intra-operative blood loss of huge meningioma resection patients on average was over 1000ml. Intra-operative massive hemorrhage was associated with longer hospital of stay, higher expense, and higher mortality. Previous studies indicated intra-operative tranexamic acid infusion would decrease blood loss for cardiac, trauma and obstetric procedures. However, limited researches focusing on the effect of tranexamic acid in neurosurgery population, with heterogenous pathologies. The purpose of this study was to investigate the effect of tranexamic acid on intra-operative blood loss in patients undergoing huge meningioma resection.

Inclusion Criteria:

• Patients undergoing elective supratentorial meningioma resection with estimated tumor diameter >5cm on brain image.
• Age between 18-65 years.
• American Society of Anaesthesiologist (ASA) physical status Ⅰ to Ⅲ
• Obtain written informed consent.

Exclusion Criteria:

• Allergic to tranexamic acid.
• History of thrombotic disease.
• History of chronic kidney disease
• Receiving other anticoagulation or antiplatelet treatment.
• Refuse to provide written informed consent