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Intra-operative blood loss of huge meningioma resection patients on average was over 1000ml. Intra-operative massive hemorrhage was associated with longer hospital of stay, higher expense, and higher mortality. Previous studies indicated intra-operative tranexamic acid infusion would decrease blood loss for cardiac, trauma and obstetric procedures. However, limited researches focusing on the effect of tranexamic acid in neurosurgery population, with heterogenous pathologies. The purpose of this study was to investigate the effect of tranexamic acid on intra-operative blood loss in patients undergoing huge meningioma resection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Continous infusion group | Active Comparator | Infusion with 20mg/kg tranexamic acid and 5mg/kg/h tranexamic acid. |
|
| Single infusion group | Active Comparator | Infusion with 20mg/kg tranexamic acid and same volume 0.9% saline. |
|
| Placebo group | Placebo Comparator | Infusion with same volume of 0.9% saline. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Continous infusion | Drug | The 20mg/kg tranexamic acid will be diluted into a 50ml syringe and infused followed by 5mg/kg/h tranexamic acid infusion. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Estimated intra-operative blood loss | Estimated intra-operative blood loss is assessed as following formula:collected blood volume in the suction canister (mL) - the volume of flushing (mL) + the volume from gauze tampon (mL). | During surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shu Li, M.D. | Contact | 8613699223065 | lishu@bjtth.org |
| Name | Affiliation | Role |
|---|---|---|
| Shu Li, M.D. | Beijing Tiantan Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Tiantan Hospital, Capital Medical University | Recruiting | Beijing | Beijing Municipality | 100070 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42115323 | Derived | Li S, Liu M, Zhang L, Ren Y, Wu Y, Yin X, Zeng M, Zhou D, Sessler DI, Peng Y. Effect of tranexamic acid on blood loss in patients undergoing resection of large meningioma: a randomized clinical trial. Sci Rep. 2026 May 11;16(1):21458. doi: 10.1038/s41598-026-52276-2. | |
| 37651373 | Derived | Yu H, Liu M, Zhang X, Ma T, Yang J, Wu Y, Wang J, Li M, Wang J, Zeng M, Zhang L, Jin H, Liu X, Li S, Peng Y. The effect of tranexamic acid on intraoperative blood loss in patients undergoing brain meningioma resections: Study protocol for a randomized controlled trial. PLoS One. 2023 Aug 31;18(8):e0290725. doi: 10.1371/journal.pone.0290725. eCollection 2023. |
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| ID | Term |
|---|---|
| D008579 | Meningioma |
| ID | Term |
|---|---|
| D009380 | Neoplasms, Nerve Tissue |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009383 | Neoplasms, Vascular Tissue |
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| Single infusion | Drug | The 20mg/kg tranexamic acid will be diluted into a 50ml syringe and infused followed by same volume of 0.9% saline. |
|
| Placebo | Drug | The 0.9% saline is administered with the same volume at the same speed as the other group. |
|
| D008577 | Meningeal Neoplasms |
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009422 | Nervous System Diseases |