Tranexamic Acid Use for Bleeding Prevention in the Surgical Treatment of Metastatic Spinal Tumor in Lung Cancer Patients

Tranexamic Acid Use for Bleeding Prevention in the Surgical Treatment of Metastatic Spinal Tumor in Lung Cancer Patients: a Triple Blinded, Randomized Controlled Trial to Assess the Efficacy of Tranexamic Acid for Hemostasis

Massive blood loss occurs in metastatic spinal tumor resection and may cause severe complications. The objective of this study is to investigate whether the use of tranexamic acid will reduce perioperative and postoperative bleeding when compared to those without use of tranexamic acid.

Inclusion Criteria:

• Diagnosed as metastatic carcinoma of the thoracolumbar spine
• solitary neoplasm involve only one segment of spine
• patients underwent separation surgery

Exclusion Criteria:

• coagulation function was abnormal preoperatively
• patients are allergic to tranexamic acid
• neoplasm involve more than one segment of spine
• patients with rich blood supply who need embolization