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Investigators will gather data on both the beneficial and harmful effects of edible cannabis of varying composition (THC-only vs. CBD-only vs. THC+CBD), and will examine the process by which older adult cannabis users decide what type of cannabis product is preferred.
Older adults are currently the fastest growing group of cannabis users in the U.S, and are more likely to use cannabis for medicinal purposes (e.g., pain, trouble sleeping, depression/anxiety) than for recreational purposes, despite having little data to guide their decisions about what type of product to use. This project utilizes a patient-centered observational design to recruit and assess older adults who are interested in using cannabis compared to a control group who is not interested in cannabis use. Investigators will gather data on both the beneficial and harmful effects of edible cannabis of varying composition (THC-only vs. CBD-only vs. THC+CBD), and will examine the process by which older adult cannabis users decide what type of cannabis product is preferred.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cannabis Users | Older adults (60 and up) who report pain, sleep problems, and/or negative mood (anxiety and/or depression) and who desire to use cannabis for these issues (n=300) |
| |
| Cannabis Non-users | Older adults (60 and up) who report pain, sleep problems, and/or negative mood (anxiety and/or depression) and do NOT desire to use cannabis for these issues (n=50) |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Choice of cannabis product | Behavioral | Participants choose and purchase their own cannabis product |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Patient Global Impression of Change | Self report of whether symptoms have improved, gotten worse, or stayed the same | 1-month, 2 months, 3 months, 4 months |
| Change in FACT-Cog | Self-report of whether cognitive function has improved, gotten worse, or stayed the same | Baseline, 1-month, 2 months, 3 months, 4 months |
| Change in Rey Auditory Verbal Learning Task | Test of whether working memory has improved, gotten worse, or stayed the same | Baseline, 1-month |
| Balance Task | Stability with eyes closed and eyes open | 1-month |
| Change in Activities Specific Balance Confidence Scale | Self-report of whether confidence in balance has improved, gotten worse, or stayed the same | Baseline, 1-month, 2 months, 3 months, 4 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Depression Anxiety Stress Scale | Self-report of whether depression, anxiety and stress have improved, gotten worse, or stayed the same | Baseline, 1-month, 2 months, 3 months, 4 months |
| Change in PROMIS Sleep Disturbance |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Blood Cannabinoids and Endocannabinoids | Quantitation of major and minor cannabinoids and endocannabinoids in blood; measure of whether cannabinoid levels change over time | Baseline, 1-month |
| Change in Neurofilament Light |
Inclusion Criteria:
Exclusion Criteria:
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Older adults experiencing problems with pain, sleep, depression or anxiety who either wish to use cannabis or who do not wish to cannabis
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado Boulder | Boulder | Colorado | 80309 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41677842 | Derived | Sundali E, Lisano JK, Bryan AD, Skrzynski CJ. Heart rate response to cannabis in active older adults. Eur J Appl Physiol. 2026 Jun;126(6):3315-3321. doi: 10.1007/s00421-026-06152-6. Epub 2026 Feb 12. |
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Self-report of whether sleep quality has improved, gotten worse, or stayed the same
| Baseline, 1-month, 2 months, 3 months, 4 months |
| Change in PROMIS Fatigue | Measure of whether experience of fatigue has improved, gotten worse, or stayed the same | Baseline, 1-month, 2 months, 3 months, 4 months |
| Change in PROMIS Pain Interference | Self-report of whether the extent to which pain interferes with daily life activities has improved, gotten worse, or stayed the same | Baseline, 1-month, 2 months, 3 months, 4 months |
| Change in pain Intensity past 7 days | Self-report of whether intensity of pain has improved, gotten worse, or stayed the same | Baseline, 1-month, 2 months, 3 months, 4 months |
| Current Pain Intensity | Self-reported intensity of pain right now | 1-month |
| Addiction Research Center Inventory Marijuana Survey | Acute subjective effects of cannabis | 1-month |
| Drug Effects Questionnaire | Acute subjective effects of cannabis | 1-month |
| Profile of Mood States | Acute mood effects of cannabis | 1-month |
| Change in PROMIS Global Health | Self-report of whether general health and functioning has improved, gotten worse, or stayed the same | Baseline, 1-month, 2 months, 3 months, 4 months |
| Change in Polypharmacy | Measure of whether number and dosage of current medications has improved, gotten worse, or stayed the same | Baseline, 1-month, 2 months, 3 months, 4 months |
| Change in Online Timeline Follow-back Assessment | 30-day retrospective report of substance use (cannabis, alcohol, other drugs); measure of whether substance use has improved, gotten worse, or stayed the same | Baseline, 1-month, 2 months, 3 months, 4 months |
| Change in Marijuana Consumption Questionnaire | Self-report of whether frequency and quantity of cannabis use changes over time or stays the same | Baseline, 1-month, 2 months, 3 months, 4 months |
Quantitation of neuronal damage in blood; measure of whether damage change over time
| Baseline, 1-month |
| Change in Expectancies about Cannabis | Self-report of whether opinions about the health effects of cannabis has improved, gotten worse, or stayed the same | Baseline, 1-month, 2 months, 3 months, 4 months |
| Change in Flanker Inhibitory Control and Attention task | Measure of whether inhibition has improved, gotten worse, or stayed the same | Baseline, 1-month |