Acute Neuroendocrine Response to Intravenous Infusion of Diclofenac Sodium

Acute Neuroendocrine Response to Intravenous Infusion of Diclofenac Sodium

The effects of acute administration of non-steroidal anti-inflammatory drugs (NSAIDs) on the neuroendocrine regulation of hydro-electrolytic metabolism are not precisely known to date.

Although the mechanism by which NSAIDs favor the antidiuretic action of vasopressin (AVP) in the kidney has been partially elucidated, their influence on the mechanisms responsible for regulating its secretion are less known. The interactions between NSAIDs and natriuretic peptides are also not entirely certain.

The present pharmacological research study therefore aims to investigate, in a cohort of healthy subjects, the acute effects of intravenous infusion of diclofenac sodium on the neuroendocrine regulation systems of water and salt balance (i.e. the antidiuretic axis and the system of natriuretic peptides).

Inclusion Criteria:

- Any adult healthy subject (with age 20-50 years old) not meeting any of the exclusion criteria listed below

Exclusion Criteria:

• BMI < 18.5 kg/m2 or > 25 kg/m2
• Any active pharmacological treatment
• Pregnancy or breastfeeding
• History of polyuria/polydipsia syndrome
• History of dysionia
• History of peptic disease
• History of gastrointestinal bleeding
• History of kidney disease
• History of heart disease
• History of asthma
• Known allergy to NSAIDs
• Any current acute medical condition