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Investigate the supersaturation and precipitation behaviour of diclofenac in the stomach of healthy volunteers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nutritional State | Active Comparator | Fed vs. Fasted State Diclofenac potassium 50 mg |
|
| Use of a PPI | Active Comparator | Nexiam (esomeprazole) 40 mg Diclofenac potassium 50 mg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diclofenac potassium 50 mg | Drug | Diclofenac potassium 50 mg |
|
| Measure | Description | Time Frame |
|---|---|---|
| Area under the Concentration - Time Curve | Every 10 minutes for 2 h |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D004008 | Diclofenac |
| ID | Term |
|---|---|
| D010648 | Phenylacetates |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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