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| ID | Type | Description | Link |
|---|---|---|---|
| R01AT011429 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Center for Complementary and Integrative Health (NCCIH) | NIH |
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This study will perform magnetic resonance imaging (MRI) measurements of hemodynamics and cerebrospinal fluid flow across breathing tasks and during breath-locked neuromodulation.
Cerebrospinal fluid (CSF) flow is essential for brain health, as it clears waste products from the brain. This study will investigate how breathing affects the flow of CSF around the brain. The investigators will perform high resolution magnetic resonance imaging (MRI) scans in participants who are breathing in specific patterns or performing simple tasks and test the effects on CSF flow. Participants will complete an imaging study visit in which the investigators will image their brain activity while they perform simple tasks, including paced breathing tasks. The participants will be split into two arms: (1) paced breathing (25 participants low resolution, 15 participants high resolution), (2) transcutaneous vagal nerve stimulation (25 participants low resolution, 15 participants high resolution). The MRI scans will take place in the 7 Tesla MRI scanner at Massachusetts General Hospital.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Breath task | Experimental | Participants will breathe in specific patterns. |
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| Transcutaneous vagal nerve stimulation | Experimental | Participants will receive transcutaneous vagal nerve stimulation in specific patterns. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcutaneous vagal nerve stimulation | Device | Noninvasive stimulation vs sham stimulation will be delivered via an auricular device. |
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| Measure | Description | Time Frame |
|---|---|---|
| functional magnetic resonance imaging (fMRI) signals | fMRI measures of hemodynamic responses. Units: percent signal change | During study (2 hours) |
| Cerebrospinal fluid (CSF) signals | MR-based measures of CSF signals. Units: percent signal change | During study (2 hours) |
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate | Heart rate variability will be calculated. Units: milliseconds (ms) | During study ( 2 hours) |
| Pulse oximetry | Amplitude of pulse oximetry signal. Units: arbitrary (no physical units are output by this system) |
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Inclusion Criteria:
Exclusion Criteria:
Exclusion for transcutaneous vagus nerve stimulation (tVNS) arm:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jessica Yee, BS | Contact | 7742852038 | jessyee@bu.edu | |
| Courtney Zambello, BA | Contact | 7812019815 | cgz@bu.edu |
| Name | Affiliation | Role |
|---|---|---|
| Laura Lewis, PhD | Boston University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Massachusetts General Hospital | Recruiting | Boston | Massachusetts | 02114 | United States |
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| Breathing task | Behavioral | Participants will be asked to breathe in specific patterns. |
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| During study ( 2 hours) |
| Respiratory physiology timing | Breath timing. Units: Hertz (Hz) | During study (2 hours) |
| Respiratory physiology amplitude | Breath amplitude. Units: arbitrary (no physical units output by this sensor) | During study (2 hours) |
| Boston University - Charles River Campus | Recruiting | Boston | Massachusetts | 02215 | United States |
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