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In an exploratory observational pilot study, the investigators will focus on the effects of short-term circadian misalignment induced by shift work on multidimensional measurements including glucose excursion, metabolic health, circadian rhythms (measured in vitro and in vivo), sleep/wake cycles and ambient light, eating and activity patterns, well-being and attention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Shift workers | Measurements repeated during a series of day shifts and during a series of night shifts |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exposure to shift work | Other | Detailed questionnaire adapted from the Standard Shiftwork Index, measured at inclusion |
|
| Measure | Description | Time Frame |
|---|---|---|
| Difference in glucose excursion | As measured by Continuous Glucose Monitoring | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Difference in fasting glucose | As measured by clinical chemistry (mmol/L) | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Difference in weight |
| Measure | Description | Time Frame |
|---|---|---|
| Difference in blood metabolomic parameters | As measured by high-throughput mass spectrometry metabolomics, semi-quantitative identification of small metabolites involved in carbohydrate, fat, protein, and steroid metabolism | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
Inclusion Criteria:
Exclusion Criteria:
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Shift workers
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| Name | Affiliation | Role |
|---|---|---|
| Tinh-Hai Collet, MD | Geneva University Hospitals, Geneva | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Geneva University Hospitals | Geneva | 1211 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40485643 | Result | Hartmeyer SL, Phillips NE, Jassil FC, Joris C, Dibner C, Collet TH, Andersen M. Multi-Wearable Approach for Monitoring Diurnal Light Exposure and Body Rhythms in Nightshift Workers. Acta Physiol (Oxf). 2025 Jul;241(7):e70069. doi: 10.1111/apha.70069. |
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serum, plasma
Body weight (Kg)
| Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Difference in waist circumference | Waist circumference (cm) assessed with a measuring tape | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Difference in lipid profile | Total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol measured by clinical chemistry (mmol/L) | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Difference in blood hormonal profile | Insulin (mIU/L), thyroid-stimulating hormone (mIU/L), cortisol (nmol/L) measured by clinical chemistry | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Difference in eating duration | Time from the first to last caloric intake over a 24-hour period | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Difference in nutrient intake | Total calorie and macronutrient intake over a 24-hour period | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Difference in systolic and diastolic blood pressure | As measured by blood pressure arm cuff | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Difference in heart rate variability | As measured by wearable sensor | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Difference in physical activity | As measured by actigraphy and the International Physical Activity Questionnaire | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Difference in sleep/wake cycles | As measured by actigraphy | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Difference in sleep quality | As measured by the Pittsburgh Sleep Quality Index (PSQI), score ranges from 0 to 21 points, 0 indicating no difficulty and 21 severe difficulties | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Difference in attention and sleepiness | As measured by the Sustained Attention to Response Test | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Difference in well-being | As measured by the World Health Organization-5 questionnaire (WHO-5), score ranges from 0 to 25, 0 indicating worst possible and 25 best possible | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Difference in mental health outcomes | As measured by the Patient Health Questionnaire-9 (PHQ-9), score ranges from 0 to 27, 0 indicating no depression and 27 severe depression | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Difference in lipid metabolism |
As measured by high-throughput mass spectrometry lipidomics |
| Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Difference in the exposure to ambient light | As measured by wearable spectrometer and the light exposure behaviour assessment (LEBA) questionnaire | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |
| Difference in the core body temperature | As measured by a wearable skin temperature and heat transfer sensor | Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months |