Evaluation of GvHD Damage on Medullary Mesenchymal Stem Cells

Prospective Multicenter Study for the Evaluation of GvHD Damage on Medullary Mesenchymal Stem Cells - GvHD Damage on MSCs

Spontaneous, multicenter, prospective, non-pharmacological study. At the diagnosis of acute or chronic GvHD after HSCT, bone marrow cells will be analysed for MSC content and properties. Bone marrow aspirate will be performed according to usual clinical practise

Inclusion Criteria:

• Patients (children and adults) developing acute or chronic GvHD after HSCT.
• Age 6 months- month-99 years,
• Landsky-Karnofsky> 70%,
• Acute or chronic GvHD needing further immunosuppressive treatment.

Exclusion Criteria:

• Anything not included in the inclusion criteria.