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The aim of this project is to assess patients' opinions, attitudes, and ideas regarding the administration of OLPs in clinical practice, although they might never have had contact to placebos. A qualitative approach is used and online focus group discussions (FGD) with patients with different clinical conditions, entailing chronic back pain, Parkinson's disease, chronic migraine, chemotherapy induced emesis, and menopausal complaints are conducted.
Substantial placebo effects have been known for several decades for a multitude of physical as well as psychological complaints. It is essential to test the acceptability of Open-label placebos (OLPs) of patients and health professionals. The aim of this project is to assess patients' opinions, attitudes, and ideas regarding the administration of OLPs in clinical practice, although they might never have had contact to placebos. A qualitative approach is used and online focus group discussions (FGD) with patients with different clinical conditions, entailing chronic back pain, Parkinson's disease, chronic migraine, chemotherapy induced emesis, and menopausal complaints are conducted. A semi-structured topic guide with open-ended questions will be used.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chronic back pain |
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| Clinically significant menopausal complaints |
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| Parkinson's disease |
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| Migraine |
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| Cancer-related emesis/nausea |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| focus group discussions (FGD) | Other | FGD to explore patients' attitudes/ concerns towards OLP implementation into clinical practice by means of assessment of qualitative information: 1) Patients' attitudes towards clinical usage of OLPs 2) Personal acceptance of OLP intervention 3) Perceived ideas, concerns regarding OLP implementation. Core questions: 1) Attitudes: After all that I told you about placebos, i.e. that there is a concept that patients are openly elucidated that they receive placebos: What does this elicit in you/What is your opinion on this? How do you like the idea? 2) Context of Acceptance: Under which conditions would you personally take placebos knowing that they are placebos? 3) Concerns: Why would you not take openly administered placebos? 4) Ideas for clinical implication: How could an open placebo intervention look like in the hospital? Where could it be possible to receive placebos and how could a placebo intervention in the best manner take place? What would be important from your point of view? |
| Measure | Description | Time Frame |
|---|---|---|
| Qualitative data analysis | Qualitative data analysis using the approach of "Thematic Analysis". This approach helps to identify, analyze, and interpret patterns of meanings in the form of upcoming "themes" in the qualitative data. Important "themes" deriving from the group discussion between the respective patient groups are explored. . In this manner, important subjective factors of OLP acceptance or non-acceptance can be revealed as well as boundaries of differences within opinions. | one time assessment at baseline with a duration from max. 60 minutes. |
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Inclusion Criteria:
Signed informed Consent form (see Appendix)
Capable of consent (language/cognitive)
At least 18 years of age
Ability to attend an online conference in regard of physical and psychological condition and technical knowhow and equipment
In addition, participants have to be affected by one of the following conditions/disorders:
Exclusion Criteria:
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Patients will be recruited with help of physicians from the following clinics:
University Hospital Basel Anästhesiologie: Schmerzmedizin Frauenklinik: Gynäkologische Sozialmedizin und Psychosomatik Neurologie: Migräne und Morbus Parkinson Sprechstunden Onkologie und Psychoonkologie Privatklinik Hohenegg AG. Interested patients will receive a flyer of the study and will be asked if they prefer to enter in contact with the study team by themselves or if the study team is allowed to call the patient.
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| Name | Affiliation | Role |
|---|---|---|
| Antje Frey Nascimento, Dr. | University of Basel, Faculty of Psychology, Division of Clinical Psychology and Psychotherapy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Basel, Faculty of Psychology, Division of Clinical Psychology and Psychotherapy | Basel | 4055 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40823423 | Derived | Frey Nascimento A, Bakis B, Gaab J, Schneider T, Papadopoulou A, Ritter M, Bernstein MH, Blease CR, Locher C. Talking placebo: a qualitative study of patients' attitudes toward open-label placebo implementation into clinical practice. Front Psychol. 2025 Jul 31;16:1533663. doi: 10.3389/fpsyg.2025.1533663. eCollection 2025. |
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