Consequences of Eccentric Cycling on Exercise-related Neuromuscular Responses and Biomarkers in Breast Cancer Patients

Consequences of Eccentric Cycling on Exercise-related Neuromuscular Responses and Biomarkers in Breast Cancer Patients

This is a monocentric, prospective and interventional study aimed to investigating the physiological responses of eccentric compared to concentric cycling realized 1) at the same metabolic demand and 2) at the same mechanical power output. In order to compare the physiological responses between these two cycling modalities, 3 cycling sessions should be performed for each patient where concentric one will serve as reference / comparison to the eccentric one:

• Session (a): eccentric cycling
• Session (b): high intensity concentric cycling realized at the same mechanical power output than eccentric cycling
• Session (c): low intensity concentric cycling realized at the same metabolic demand than eccentric cycling The 3 sessions will be performed for each patient and order will be randomized.

For each participant, 10 visits will be realized as followed:

Visit 1: determination of maximal O2 consumption (VO2max) and first familiarization session to eccentric cycling Visits 2, 3 and 4: second, third and fourth eccentric cycling familiarization sessions Visits 5, 7 and 9: cycling sessions (a), (b) and (c) attributed in a random order Visits 6, 8 and 10: post-24h measurements after cycling sessions

Inclusion Criteria:

• Woman who completed (neo)adjuvant chemotherapy since less than 1 year for a breast cancer
• Woman under hormonotherapy, or menopausal woman, or woman in amenorrhea

Exclusion Criteria:

• Pregnant and nursing woman
• psychiatric, musculoskeletal or neurological disorders
• presenting at least one contraindication to the use of the transcranial magnetic stimulation
• presenting at least one contraindication to the realisation of the maximum effort test